Long Liang1,2, Wen-Bo Chen1, Kannie W Y Chan3, Yu-Guo Li3, Bin Zhang1,2, Chang-Hong Liang1, Guan-Shu Liu3, Shui-Xing Zhang4. 1. Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, No. 106 Zhong shan Er Road, 510080, Guangzhou, Guangdong Province, China. 2. Graduate College, Southern Medical University, Guangzhou, China. 3. Russell H. Morgan Department of Radiology and Radiological Sciences, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. 4. Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, No. 106 Zhong shan Er Road, 510080, Guangzhou, Guangdong Province, China. shui7515@126.com.
Abstract
OBJECTIVES: To investigate the potential of intravoxel incoherent motion (IVIM) to assess the renal pathophysiological process in contrast-induced acute kidney injury (CIAKI). METHODS: Twenty-seven rats were induced with CIAKI model, six rats were imaged longitudinally at 24 h prior to and 30 min, 12, 24, 48, 72 and 96 h after administration; three rats were randomly chosen from the rest for serum creatinine and histological studies. D, f, D* and ADC were calculated from IVIM, and renal blood flow (RBF) was obtained from arterial spin labelling (ASL). RESULTS: A progressive reduction in D and ADC was observed in cortex (CO) by 3.07 and 8.62 % at 30 min, and by 25.77 and 28.16 % at 48 h, respectively. A similar change in outer medulla (OM) and inner medulla (IM) was observed at a later time point (12-72 h). D values were strongly correlated with ADC (r = 0.885). As perfusion measurement, a significant decrease was shown for f in 12-48 h and an increase in 72-96 h. A slightly different trend was found for D*, which was decreased by 26.02, 21.78 and 10.19 % in CO, OM and IM, respectively, at 30 min. f and D* were strongly correlated with RBF in the cortex (r = 0.768, r = 0.67), but not in the medulla. CONCLUSIONS: IVIM is an effective imaging tool for monitoring progress in renal pathophysiology undergoing CIAKI. KEY POINTS: • IVIM analysis permits separate quantification of diffusion and perfusion. • IVIM can provide useful biomarkers ifor changes in renal pathophysiology. • IVIM can be useful for monitoring progress in renal pathophysiology undergoing CIAKI.
OBJECTIVES: To investigate the potential of intravoxel incoherent motion (IVIM) to assess the renal pathophysiological process in contrast-induced acute kidney injury (CIAKI). METHODS: Twenty-seven rats were induced with CIAKI model, six rats were imaged longitudinally at 24 h prior to and 30 min, 12, 24, 48, 72 and 96 h after administration; three rats were randomly chosen from the rest for serum creatinine and histological studies. D, f, D* and ADC were calculated from IVIM, and renal blood flow (RBF) was obtained from arterial spin labelling (ASL). RESULTS: A progressive reduction in D and ADC was observed in cortex (CO) by 3.07 and 8.62 % at 30 min, and by 25.77 and 28.16 % at 48 h, respectively. A similar change in outer medulla (OM) and inner medulla (IM) was observed at a later time point (12-72 h). D values were strongly correlated with ADC (r = 0.885). As perfusion measurement, a significant decrease was shown for f in 12-48 h and an increase in 72-96 h. A slightly different trend was found for D*, which was decreased by 26.02, 21.78 and 10.19 % in CO, OM and IM, respectively, at 30 min. f and D* were strongly correlated with RBF in the cortex (r = 0.768, r = 0.67), but not in the medulla. CONCLUSIONS: IVIM is an effective imaging tool for monitoring progress in renal pathophysiology undergoing CIAKI. KEY POINTS: • IVIM analysis permits separate quantification of diffusion and perfusion. • IVIM can provide useful biomarkers ifor changes in renal pathophysiology. • IVIM can be useful for monitoring progress in renal pathophysiology undergoing CIAKI.
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