| Literature DB >> 26372891 |
Kathleen Coelingh1, Ifedapo Rosemary Olajide2, Peter MacDonald1, Ram Yogev3.
Abstract
Evidence of high efficacy of live attenuated influenza vaccine (LAIV) from randomized controlled trials is strong for children 2-6 years of age, but fewer data exist for older school-age children. We reviewed the published data on efficacy and effectiveness of LAIV in children ≥5 years. QUOSA (Elsevier database) was searched for articles published from January 1990 to June 2014 that included 'FluMist', 'LAIV', 'CAIV', 'cold adapted influenza vaccine', 'live attenuated influenza vaccine', 'live attenuated cold adapted' or 'flu mist'. Studies evaluated included randomized controlled trials, effectiveness and indirect protection studies. This review demonstrates that LAIV has considerable efficacy and effectiveness in school-age children.Entities:
Keywords: effectiveness; efficacy; influenza vaccine; live attenuated influenza vaccine; school-age children
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Year: 2015 PMID： 26372891 DOI： 10.1586/14760584.2015.1078732
Source DB: PubMed Journal: Expert Rev Vaccines ISSN： 1476-0584 Impact factor: 5.217