Thelma Beatriz González-Castro1, Carlos Alfonso Tovilla-Zárate2, Yazmín Hernández-Díaz3, Ana Fresán4, Isela E Juárez-Rojop5, Jorge L Ble-Castillo6, Lilia López-Narváez7, Alma Genis8, Mervyn Manuel Hernández-Alvarado9. 1. Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Jalpa de Méndez, Cunduacán, Tabasco, Mexico. Electronic address: thelma.glez.castro@gmail.com. 2. Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Comalcalco, Comalcalco, Tabasco, Mexico. Electronic address: alfonso_tovillaz@yahoo.com.mx. 3. Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Jalpa de Méndez, Cunduacán, Tabasco, Mexico. Electronic address: yazmin.hdez.diaz@gmail.com. 4. Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico, D.F., Mexico. Electronic address: fresan@imp.edu.mx. 5. Universidad Juárez Autónoma de Tabasco, División Académica de Ciencias de la Salud, Villahermosa, Tabasco, Mexico. Electronic address: iselajua22@yahoo.com.mx. 6. Universidad Juárez Autónoma de Tabasco, División Académica de Ciencias de la Salud, Villahermosa, Tabasco, Mexico. Electronic address: jblecastillo@hotmail.com. 7. Hospital General de Yajalón, Yajalón, Chiapas, Mexico. Electronic address: dralilialonar@yahoo.com.mx. 8. Instituto Nacional de Medicina Genómica (INMEGEN), Servicios de Atención Psiquiátrica (SAP), Secretaría de Salud, México, D.F., Mexico. Electronic address: adgenis@inmegen.gob.mx. 9. Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Comalcalco, Comalcalco, Tabasco, Mexico. Electronic address: thelma.glezcastro@yahoo.com.mx.
Abstract
INTRODUCTION: Schizophrenia affects between 0.3% and 2% of the worldwide population. A genetic contribution has been postulated in the development of this disorder. Genes such as ApoE have been implicated in the neurodevelopment associated with schizophrenia in case-control and meta-analysis studies, but the results remain inconclusive. Due to this, the aim of the present study was to explore the association between ApoE and schizophrenia through a meta-analysis. MATERIAL AND METHODS: We collected all relevant studies by searching PubMed and EBSCO databases. The pooled odds ratios with 95% confidence intervals were calculated to estimate the association. The following models were evaluated: A) ε4 vs ε3, B) ε4 vs ε2, C) ε4 vs ε3+ε2, D) Caucasian population and E) Asian population. Statistical analyses were performed using EPIDAT 3.1 software. RESULTS: The meta-analyses comprised 28 association studies, which included 4703 controls and 3452 subjects with schizophrenia. A significant protective effect was found for allele ε3 in the Asian population (OR=0.73, 95% CI=0.54-0.98). No significant associations were observed in the other models and populations analyzed. CONCLUSIONS: Our meta-analysis suggests a protective association between ApoE allele ε3 and schizophrenia in the Asian population.
INTRODUCTION:Schizophrenia affects between 0.3% and 2% of the worldwide population. A genetic contribution has been postulated in the development of this disorder. Genes such as ApoE have been implicated in the neurodevelopment associated with schizophrenia in case-control and meta-analysis studies, but the results remain inconclusive. Due to this, the aim of the present study was to explore the association between ApoE and schizophrenia through a meta-analysis. MATERIAL AND METHODS: We collected all relevant studies by searching PubMed and EBSCO databases. The pooled odds ratios with 95% confidence intervals were calculated to estimate the association. The following models were evaluated: A) ε4 vs ε3, B) ε4 vs ε2, C) ε4 vs ε3+ε2, D) Caucasian population and E) Asian population. Statistical analyses were performed using EPIDAT 3.1 software. RESULTS: The meta-analyses comprised 28 association studies, which included 4703 controls and 3452 subjects with schizophrenia. A significant protective effect was found for allele ε3 in the Asian population (OR=0.73, 95% CI=0.54-0.98). No significant associations were observed in the other models and populations analyzed. CONCLUSIONS: Our meta-analysis suggests a protective association between ApoE allele ε3 and schizophrenia in the Asian population.
Authors: Viktoria Johansson; Joel Jakobsson; Rebecca G Fortgang; Henrik Zetterberg; Kaj Blennow; Tyrone D Cannon; Christina M Hultman; Lennart Wetterberg; Mikael Landén Journal: Eur Arch Psychiatry Clin Neurosci Date: 2016-12-30 Impact factor: 5.270
Authors: Fidel Vila-Rodriguez; Donna J Lang; Heather Baitz; Kristina Gicas; Allen E Thorton; Thomas S Ehmann; Geoff N Smith; Alasdair M Barr; Ivan J Torres; Lili C Kopala; G William MacEwan; Daniel J Müller; James L Kennedy; William G Honer Journal: Neuropsychiatr Dis Treat Date: 2017-12-08 Impact factor: 2.570