| Literature DB >> 26372329 |
Aliaksei V Pukin1, Arwin J Brouwer, Leonie Koomen, H C Quarles van Ufford, Johan Kemmink, Nico J de Mol, Roland J Pieters.
Abstract
A new divalent highly potent inhibitor of the Pseudomonas aeruginosa lectin and virulence factor LecA was prepared. It contains two thiourea linkages which were found to be in the Z,Z isomeric form. This brings the spacer into an elongated conformation required to bridge the two binding sites, which results in the chelating binding mode responsible for the high potency.Entities:
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Year: 2015 PMID： 26372329 DOI： 10.1039/c5ob01452b
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876