Mei Chen1, Chi-Hsuan Chang1, Lin Tao1, Chensheng Lu2. 1. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. 2. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts cslu@hsph.harvard.edu.
Abstract
CONTEXT: There is an increasing concern about chronic low-level pesticide exposure during childhood and its influence on childhood cancers. OBJECTIVE: In this meta-analysis, we aimed to examine associations between residential childhood pesticide exposures and childhood cancers. DATA SOURCES: We searched all observational studies published in PubMed before February 2014 and reviewed reference sections of articles derived from searches. STUDY SELECTION: The literature search yielded 277 studies that met inclusion criteria. DATA EXTRACTION: Sixteen studies were included in the meta-analysis. We calculated effect sizes and 95% confidence intervals (CIs) by using a random effect model with inverse variance weights. RESULTS: We found that childhood exposure to indoor but not outdoor residential insecticides was associated with a significant increase in risk of childhood leukemia (odds ratio [OR] = 1.47; 95% CI, 1.26-1.72; I(2) = 30%) and childhood lymphomas (OR = 1.43; 95% CI, 1.15-1.78; I(2) = 0%). A significant increase in risk of leukemia was also associated with herbicide exposure (OR = 1.26; 95% CI, 1.10-1.44; I(2) = 0%). Also observed was a positive but not statistically significant association between childhood home pesticide or herbicide exposure and childhood brain tumors. LIMITATIONS: The small number of studies included in the analysis represents a major limitation of the current analysis. CONCLUSIONS: Results from this meta-analysis indicated that children exposed to indoor insecticides would have a higher risk of childhood hematopoietic cancers. Additional research is needed to confirm the association between residential indoor pesticide exposures and childhood cancers. Meanwhile, preventive measures should be considered to reduce children's exposure to pesticides at home.
CONTEXT: There is an increasing concern about chronic low-level pesticide exposure during childhood and its influence on childhood cancers. OBJECTIVE: In this meta-analysis, we aimed to examine associations between residential childhood pesticide exposures and childhood cancers. DATA SOURCES: We searched all observational studies published in PubMed before February 2014 and reviewed reference sections of articles derived from searches. STUDY SELECTION: The literature search yielded 277 studies that met inclusion criteria. DATA EXTRACTION: Sixteen studies were included in the meta-analysis. We calculated effect sizes and 95% confidence intervals (CIs) by using a random effect model with inverse variance weights. RESULTS: We found that childhood exposure to indoor but not outdoor residential insecticides was associated with a significant increase in risk of childhood leukemia (odds ratio [OR] = 1.47; 95% CI, 1.26-1.72; I(2) = 30%) and childhood lymphomas (OR = 1.43; 95% CI, 1.15-1.78; I(2) = 0%). A significant increase in risk of leukemia was also associated with herbicide exposure (OR = 1.26; 95% CI, 1.10-1.44; I(2) = 0%). Also observed was a positive but not statistically significant association between childhood home pesticide or herbicide exposure and childhood brain tumors. LIMITATIONS: The small number of studies included in the analysis represents a major limitation of the current analysis. CONCLUSIONS: Results from this meta-analysis indicated that children exposed to indoor insecticides would have a higher risk of childhood hematopoietic cancers. Additional research is needed to confirm the association between residential indoor pesticide exposures and childhood cancers. Meanwhile, preventive measures should be considered to reduce children's exposure to pesticides at home.
Authors: Clinton Hall; Johnni Hansen; Ondine S von Ehrenstein; Di He; Jørn Olsen; Beate Ritz; Julia E Heck Journal: Int Arch Occup Environ Health Date: 2020-02-05 Impact factor: 3.015
Authors: Pierre-Alexandre Vidi; Kim A Anderson; Haiying Chen; Rebecca Anderson; Naike Salvador-Moreno; Dana C Mora; Carolyn Poutasse; Paul J Laurienti; Stephanie S Daniel; Thomas A Arcury Journal: Mutat Res Date: 2017-07-16 Impact factor: 2.433
Authors: Alberto Cárceles-Álvarez; Juan A Ortega-García; Fernando A López-Hernández; Mayra Orozco-Llamas; Blanca Espinosa-López; Esther Tobarra-Sánchez; Lizbeth Alvarez Journal: Environ Res Date: 2017-04-26 Impact factor: 6.498
Authors: Abbey Alkon; Robert B Gunier; Kimberly Hazard; Rosemary Castorina; Peter D Hoffman; Richard P Scott; Kim A Anderson; Asa Bradman Journal: J Pediatr Health Care Date: 2021-10-08 Impact factor: 1.812
Authors: Carlotta Malagoli; Sofia Costanzini; Julia E Heck; Marcella Malavolti; Gianfranco De Girolamo; Paola Oleari; Giovanni Palazzi; Sergio Teggi; Marco Vinceti Journal: Int J Hyg Environ Health Date: 2016-09-21 Impact factor: 5.840
Authors: Todd P Whitehead; Catherine Metayer; Joseph L Wiemels; Amanda W Singer; Mark D Miller Journal: Curr Probl Pediatr Adolesc Health Care Date: 2016-10