Literature DB >> 26370745

Diabetic Foot Infection: Preliminary Results of a Fast-Track Program with Early Endovascular Revascularization and Local Surgical Treatment.

Nicola Troisi1, Leonardo Ercolini2, Emiliano Chisci2, Cristiana Baggiore3, Tania Chechi3, Francesco Manetti3, Barbara Del Pin3, Roberto Virgili3, Giangiuseppe Alberti Lepri3, Giancarlo Landini3, Stefano Michelagnoli2.   

Abstract

BACKGROUND: To demonstrate that a fast-track program consisting in early endovascular revascularization and local surgical treatment saves tissue in patients with diabetic foot infection (DFI).
METHODS: Between January and December 2014, 48 patients with DFI underwent early endovascular revascularization and local surgical treatment at our Diabetic Foot Center. In all cases, endovascular revascularization and local surgical treatment were performed within 1 week from the diagnosis of infection and during the same hospital stay. One-year outcomes were evaluated in terms of survival, primary patency, primary-assisted patency, secondary patency, absence of target lesion restenosis (TLR), and limb salvage.
RESULTS: The patients were predominantly males (34 of 48, 70.8%) with a mean age of 72.4 years (range, 51-91). The target vessel was a tibial artery in 34 cases (70.8%). Surgical treatment consisted of debridement without bone resection in 27 cases (56.2%), toe and/or ray amputation in 15 cases (31.2%), Lisfranc amputation in 2 cases (4.2%), transmetatarsal amputation in 2 cases (4.2%). In the remaining 2 cases, a leg amputation was necessary with an overall 30-day major amputation rate of 4.2%. During the follow-up (mean duration 6.9 months, range 1-12) healing of the lesions was obtained in 30 cases (62.5%). Estimated 12-month survival, primary patency, primary-assisted patency, secondary patency, absence of TLR, and limb salvage rates were 83.5%, 53.4%, 65%, 65%, 60.7%, and 86.6%, respectively.
CONCLUSIONS: A fast-track program consisting in early endovascular revascularization and local surgical treatment contributes to our experience in limiting amputation levels in patients with DFI. A multidisciplinary approach and adoption of diabetic foot triage are essential to achieve these outcomes.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2015        PMID: 26370745     DOI: 10.1016/j.avsg.2015.07.015

Source DB:  PubMed          Journal:  Ann Vasc Surg        ISSN: 0890-5096            Impact factor:   1.466


  2 in total

1.  The infection characteristics and autophagy defect of dermal macrophages in STZ-induced diabetic rats skin wound Staphylococcus aureus infection model.

Authors:  Xiaoying Xie; Rihui Zhong; Ling Luo; Xianghua Lin; Lisi Huang; Songyin Huang; Lijia Ni; Baiji Chen; Rui Shen; Li Yan; Chaohui Duan
Journal:  Immun Inflamm Dis       Date:  2021-10-14

Review 2.  Therapeutic application of adipose-derived stromal vascular fraction in diabetic foot.

Authors:  Xiansheng Zhao; Jiamin Guo; Fangfang Zhang; Jue Zhang; Delin Liu; Wenjun Hu; Han Yin; Liang Jin
Journal:  Stem Cell Res Ther       Date:  2020-09-14       Impact factor: 6.832

  2 in total

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