Literature DB >> 26370152

Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis.

Xuehe Xu1, David S Watt1, Chunming Liu2.   

Abstract

Thymine DNA glycosylase (TDG) is a multifunctional protein that plays important roles in DNA repair, DNA demethylation, and transcriptional regulation. These diverse functions make TDG a unique enzyme in embryonic development and carcinogenesis. This review discusses the molecular function of TDG in human cancers and the previously unrecognized value of TDG as a potential target for drug therapy.
© The Author 2015. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

Entities:  

Keywords:  DNA demethylation; DNA repair; TDG; cancer; transcription

Mesh：

Substances：

Year:  2015        PMID： 26370152      PMCID： PMC4689155          DOI： 10.1093/abbs/gmv083

Source DB:  PubMed          Journal:  Acta Biochim Biophys Sin (Shanghai)        ISSN： 1672-9145            Impact factor:   3.848


  75 in total

1.  Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability.

Authors:  Daniel Cortázar; Christophe Kunz; Jim Selfridge; Teresa Lettieri; Yusuke Saito; Eilidh MacDougall; Annika Wirz; David Schuermann; Angelika L Jacobs; Fredy Siegrist; Roland Steinacher; Josef Jiricny; Adrian Bird; Primo Schär
Journal:  Nature       Date:  2011-01-30       Impact factor: 49.962

Review 2.  Repair and genetic consequences of endogenous DNA base damage in mammalian cells.

Authors:  Deborah E Barnes; Tomas Lindahl
Journal:  Annu Rev Genet       Date:  2004       Impact factor: 16.830

Review 3.  DNA methylation and human disease.

Authors:  Keith D Robertson
Journal:  Nat Rev Genet       Date:  2005-08       Impact factor: 53.242

4.  Human thymine DNA glycosylase binds to apurinic sites in DNA but is displaced by human apurinic endonuclease 1.

Authors:  T R Waters; P Gallinari; J Jiricny; P F Swann
Journal:  J Biol Chem       Date:  1999-01-01       Impact factor: 5.157

5.  Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53.

Authors:  Nathalia Meireles da Costa; Agnès Hautefeuille; Marie-Pierre Cros; Matias Eliseo Melendez; Timothy Waters; Peter Swann; Pierre Hainaut; Luis Felipe Ribeiro Pinto
Journal:  Cell Cycle       Date:  2012-11-19       Impact factor: 4.534

6.  The interaction between thymine DNA glycosylase and nuclear receptor coactivator 3 is required for the transcriptional activation of nuclear hormone receptors.

Authors:  Shirley Chiang; Tanya Burch; Gary Van Domselaar; Kevin Dick; Alina Radziwon; Craig Brusnyk; Megan Rae Edwards; Jessica Piper; Todd Cutts; Jingxin Cao; Xuguang Li; Runtao He
Journal:  Mol Cell Biochem       Date:  2009-08-04       Impact factor: 3.396

7.  Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population.

Authors:  Wen-Qing Li; Nan Hu; Paula L Hyland; Ying Gao; Zhao-Ming Wang; Kai Yu; Hua Su; Chao-Yu Wang; Le-Min Wang; Stephen J Chanock; Laurie Burdett; Ti Ding; You-Lin Qiao; Jin-Hu Fan; Yuan Wang; Yi Xu; Jian-Xin Shi; Fangyi Gu; William Wheeler; Xiao-Qin Xiong; Carol Giffen; Margaret A Tucker; Sanford M Dawsey; Neal D Freedman; Christian C Abnet; Alisa M Goldstein; Philip R Taylor
Journal:  Carcinogenesis       Date:  2013-03-15       Impact factor: 4.944

8.  The thymine-DNA glycosylase regulatory domain: residual structure and DNA binding.

Authors:  Caroline Smet-Nocca; Jean-Michel Wieruszeski; Vicky Chaar; Arnaud Leroy; Arndt Benecke
Journal:  Biochemistry       Date:  2008-06-24       Impact factor: 3.162

9.  Active DNA demethylation is required for complete imprint erasure in primordial germ cells.

Authors:  Yuki Kawasaki; Jiyoung Lee; Ayumi Matsuzawa; Takashi Kohda; Tomoko Kaneko-Ishino; Fumitoshi Ishino
Journal:  Sci Rep       Date:  2014-01-13       Impact factor: 4.379

10.  TET proteins and the control of cytosine demethylation in cancer.

Authors:  Laurianne Scourzic; Enguerran Mouly; Olivier A Bernard
Journal:  Genome Med       Date:  2015-01-29       Impact factor: 11.117
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  6 in total

1.  Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells.

Authors:  Jia-Bao Yan; Chien-Cheng Lai; Jin-Wei Jhu; Brendan Gongol; Traci L Marin; Shih-Chieh Lin; Hsiang-Yi Chiu; Chia-Jui Yen; Liang-Yi Wang; I-Chen Peng
Journal:  Mol Ther Oncolytics       Date:  2020-06-24       Impact factor: 7.200

Review 2.  Targeting the Proline-Glutamine-Asparagine-Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy.

Authors:  Macus Tien Kuo; Helen H W Chen; Lynn G Feun; Niramol Savaraj
Journal:  Pharmaceuticals (Basel)       Date:  2021-01-18

3.  Andrographolide Against Lung Cancer-New Pharmacological Insights Based on High-Throughput Metabolomics Analysis Combined with Network Pharmacology.

Authors:  Wen Luo; Li Jia; Jia-Wen Zhang; Dong-Jie Wang; Qiu Ren; Wei Zhang
Journal:  Front Pharmacol       Date:  2021-04-21       Impact factor: 5.810

Review 4.  Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine.

Authors:  Chen Xue; Qingfei Chu; Qiuxian Zheng; Shiman Jiang; Zhengyi Bao; Yuanshuai Su; Juan Lu; Lanjuan Li
Journal:  Signal Transduct Target Ther       Date:  2022-04-28

5.  MiR-27a-3p binds to TET1 mediated DNA demethylation of ADCY6 regulates breast cancer progression via epithelial-mesenchymal transition.

Authors:  Hao Wu; Juanjuan Qiu; Zhenru Wu; Tao He; Chen Zhou; Qing Lv
Journal:  Front Oncol       Date:  2022-08-01       Impact factor: 5.738

6.  The HOTAIRM1/miR-107/TDG axis regulates papillary thyroid cancer cell proliferation and invasion.

Authors:  Dan Li; Li Chai; Xiaqing Yu; Yingchun Song; Xuchao Zhu; Suyun Fan; Wen Jiang; Tingting Qiao; Junyu Tong; Simin Liu; Lihong Fan; Zhongwei Lv
Journal:  Cell Death Dis       Date:  2020-04-08       Impact factor: 8.469
  6 in total

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