| Literature DB >> 26369516 |
Joanne Fielding1,2, Meaghan Clough1, Shin Beh3, Lynette Millist2, Derek Sears3, Ashley N Frohman3, Nathaniel Lizak4, Jayne Lim2, Scott Kolbe5, Robert L Rennaker6, Teresa C Frohman3, Owen B White2, Elliot M Frohman3,6.
Abstract
The anatomical and functional overlap between ocular motor command circuitry and the higher-order networks that form the scaffolding for cognition makes for a compelling hypothesis that measures of ocular motility could provide a means to sensitively interrogate cognitive dysfunction in people with multiple sclerosis (MS). Such an approach may ultimately provide objective and reproducible measures of cognitive dysfunction that offer an innovative capability to refine diagnosis, improve prognostication, and more accurately codify disease burden. A further dividend may be the validation and application of biomarkers that can be used in studies aimed at identifying and monitoring preventative, protective and even restorative properties of novel neurotherapeutics in MS. This Review discusses the utility of ocular motor measures in patients with MS to characterize disruption to wide-ranging networks that support cognitive function.Entities:
Mesh：
Year: 2015 PMID： 26369516 DOI： 10.1038/nrneurol.2015.174
Source DB: PubMed Journal: Nat Rev Neurol ISSN： 1759-4758 Impact factor: 42.937