Literature DB >> 26369296

The use of growth factors, CD34(+) cells and fibrin for the management of chronic venous ulcers.

Francesco Romano1, Francesco M Paolino2,3, Barbara A Rizzo2,3, Antonio Russo4, Stephen Southworth5, Raffaele Serra6,7, Luca Gallelli8,9.   

Abstract

Chronic venous ulceration represents a very common event. Current standard treatment includes local wound care with the application of compression. We report the effects of platelet-rich plasma in patients with chronic venous ulcers, which is able to stimulate fibroblasts, macrophages and mesenchymal cells and growth factors in order to achieve re-epithelialisation and neovascularisation within the microenviroment of the wound. We also documented the efficacy of this method as the sole treatment without surgical procedures.
© 2015 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

Entities:  

Keywords:  Chronic venous ulceration; Growth factors; Platelet-rich plasma

Mesh：

Substances：

Year:  2015        PMID： 26369296      PMCID： PMC7949726          DOI： 10.1111/iwj.12500

Source DB:  PubMed          Journal:  Int Wound J        ISSN： 1742-4801            Impact factor:   3.315


  10 in total

1.  Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction.

Authors:  Luigi Fabrizio Rodella; Gaia Favero; Ramon Boninsegna; Barbara Buffoli; Mauro Labanca; Giorgio Scarì; Luigi Sacco; Tiziano Batani; Rita Rezzani
Journal:  Microsc Res Tech       Date:  2011-08       Impact factor: 2.769

2.  Effects of a new nutraceutical substance on clinical and molecular parameters in patients with chronic venous ulceration.

Authors:  Raffaele Serra; Raffaele Grande; Lucia Butrico; Gianluca Buffone; Francesco G Caliò; Aida Squillace; Barbara A Rizzo; Mafalda Massara; Francesco Spinelli; Alessia G Ferrarese; Giovanni de Caridi; Luca Gallelli; Stefano de Franciscis
Journal:  Int Wound J       Date:  2014-02-25       Impact factor: 3.315

3.  Spatial distribution of mast cells in chronic venous leg ulcers.

Authors:  S A Abd-El-Aleem; C Morgan; M W J Ferguson; C N McCollum; G W Ireland
Journal:  Eur J Histochem       Date:  2005 Jul-Sep       Impact factor: 3.188

4.  Hyperhomocysteinaemia and chronic venous ulcers.

Authors:  Stefano de Franciscis; Giovambattista De Sarro; Paola Longo; Gianluca Buffone; Vincenzo Molinari; Domenico M Stillitano; Luca Gallelli; Raffaele Serra
Journal:  Int Wound J       Date:  2013-02-19       Impact factor: 3.315

5.  A novel technique combining platelet gel, skin graft, and fibrin glue for healing recalcitrant lower extremity ulcers.

Authors:  Tim Mo Chen; Jui-Che Tsai; Thierry Burnouf
Journal:  Dermatol Surg       Date:  2010-02-19       Impact factor: 3.398

6.  Venous leg ulcer management in general practice--practice nurses and evidence based guidelines.

Authors:  Carolina Weller; Sue Evans
Journal:  Aust Fam Physician       Date:  2012-05

7.  Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin.

Authors:  Raffaele Serra; Gianluca Buffone; Daniela Falcone; Vincenzo Molinari; Monica Scaramuzzino; Luca Gallelli; Stefano de Franciscis
Journal:  Wound Repair Regen       Date:  2013-03-26       Impact factor: 3.617

8.  Effectiveness of prostaglandin E1 in patients with mixed arterial and venous ulcers of the lower limbs.

Authors:  Giovanni De Caridi; Mafalda Massara; Francesco Stilo; Francesco Spinelli; Raffaele Grande; Lucia Butrico; Stefano de Franciscis; Raffaele Serra
Journal:  Int Wound J       Date:  2014-08-05       Impact factor: 3.315

9.  Doxycycline speeds up healing of chronic venous ulcers.

Authors:  Raffaele Serra; Luca Gallelli; Gianluca Buffone; Vincenzo Molinari; Domenico M Stillitano; Camillo Palmieri; Stefano de Franciscis
Journal:  Int Wound J       Date:  2013-04-05       Impact factor: 3.315

10.  The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs.

Authors:  Raffaele Serra; Luca Gallelli; Angela Conti; Giovanni De Caridi; Mafalda Massara; Francesco Spinelli; Gianluca Buffone; Francesco Giuseppe Caliò; Bruno Amato; Simona Ceglia; Giuseppe Spaziano; Luca Scaramuzzino; Alessia Giovanna Ferrarese; Raffaele Grande; Stefano de Franciscis
Journal:  Drug Des Devel Ther       Date:  2014-05-13       Impact factor: 4.162
  10 in total
  4 in total

Review 1.  The Application of Platelet-Rich Plasma for Patients Following Total Joint Replacement: A Meta-Analysis of Randomized Controlled Trials and Systematic Review.

Authors:  Hongxin Shu; Zhenjun Huang; Xinyan Bai; Zhiyu Xia; Nanye Wang; Xiaoling Fu; Xigao Cheng; Bin Zhou
Journal:  Front Surg       Date:  2022-07-04

2.  Autologous platelet-rich plasma in the treatment of refractory corneal ulcers: A case report.

Authors:  Miguel Rechichi; Marco Ferrise; Francesco Romano; Luca Gallelli; Vincenzo Toschi; Andrea Dominijanni; Alessandro Meduri
Journal:  Am J Ophthalmol Case Rep       Date:  2020-08-21

Review 3.  Skin grafting for the treatment of chronic leg ulcers - a systematic review in evidence-based medicine.

Authors:  Raffaele Serra; Antonia Rizzuto; Alessio Rossi; Paolo Perri; Andrea Barbetta; Karim Abdalla; Santo Caroleo; Chiara Longo; Bruno Amantea; Giuseppe Sammarco; Stefano de Franciscis
Journal:  Int Wound J       Date:  2016-03-04       Impact factor: 3.315

4.  Local release of metalloproteinases and their inhibitors after a successful revascularisation procedure.

Authors:  Raffaele Grande; Gioia Brachini; Antonio V Sterpetti; Valeria Borrelli; Raffaele Serra; Francesco Pugliese; Giuseppe D'Ermo; Elvira Tartaglia; Paolo Rubino; Andrea Mingoli; Paolo Sapienza
Journal:  Int Wound J       Date:  2019-10-27       Impact factor: 3.315
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.