Literature DB >> 2636890

Increased accumulation of N-isopropyl-p-(123I)-iodoamphetamine in two cases with mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS).

K Morita1, S Ono, M Fukunaga, T Yasuda, Y Higashi, A Terao, R Morita.   

Abstract

We present two cases with mitochondrial encephalopathy with lactic acidosis and strokelike episodes (MELAS), which showed both increased and decreased accumulation of N-isopropyl-p-(123I)-iodoamphetamine (123I-IMP) in single photon emission computed tomography (SPECT). The increased accumulation of the tracer occurred, before low density appeared on conventional computed tomography, suggesting that 123I-IMP SPECT may be useful in pathophysiological study of MELAS.

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Year:  1989        PMID： 2636890     DOI： 10.1007/bf00344185

Source DB:  PubMed          Journal:  Neuroradiology        ISSN： 0028-3940            Impact factor:   2.804


  10 in total

1.  Mitochondrial encephalomyopathies: a group of neuromuscular disorders with defects in oxidative metabolism.

Authors:  Y Shapira; S Harel; A Russell
Journal:  Isr J Med Sci       Date:  1977-02

2.  Computed tomography and angiography in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes); report of 3 cases.

Authors:  K Hasuo; S Tamura; K Yasumori; A Uchino; S Goda; S Ishimoto; K Kamikaseda; Y Wakuta; M Kishi; K Masuda
Journal:  Neuroradiology       Date:  1987       Impact factor: 2.804

3.  [Regional cerebral blood flow measurement using N-isopropyl-p-[123I] iodoamphetamine and rotating gamma camera emission computed tomography].

Authors:  H Matsuda; H Seki; H Ishida; H Sumiya; S Tsuji; K Hisada; H Fujii; S Yamamoto; H Kobayashi; M Hayashi
Journal:  Kaku Igaku       Date:  1985-01

4.  Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome.

Authors:  S G Pavlakis; P C Phillips; S DiMauro; D C De Vivo; L P Rowland
Journal:  Ann Neurol       Date:  1984-10       Impact factor: 10.422

5.  Mitochondrial encephalomyopathy with lactate-pyruvate elevation and brain infarctions.

Authors:  M Kuriyama; H Umezaki; Y Fukuda; M Osame; K Koike; J Tateishi; A Igata
Journal:  Neurology       Date:  1984-01       Impact factor: 9.910

6.  Restitution of cerebral energy state, as well as of glycolytic metabolites, citric acid cycle intermediates and associated amino acids after 30 minutes of complete ischemia in rats anaesthetized with nitrous oxide or phenobarbital.

Authors:  C H Nordström; S Rehncrona; B K Siesjö
Journal:  J Neurochem       Date:  1978-02       Impact factor: 5.372

7.  Ultrastructural study of the childhood mitochondrial myopathic syndrome associated with lactic acidosis.

Authors:  Y Kobayashi; S Miyabayashi; G Takada; K Narisawa; K Tada; T Y Yamamoto
Journal:  Eur J Pediatr       Date:  1982-09       Impact factor: 3.183

8.  Mitochondrial myopathy and encephalopathy: three cases--a deficiency of NADH-CoQ dehydrogenase?

Authors:  P L Holliday; A R Climie; J Gilroy; M Z Mahmud
Journal:  Neurology       Date:  1983-12       Impact factor: 9.910

9.  Quantifying local cerebral blood flow by N-isopropyl-p-[123I]iodoamphetamine (IMP) tomography.

Authors:  D E Kuhl; J R Barrio; S C Huang; C Selin; R F Ackermann; J L Lear; J L Wu; T H Lin; M E Phelps
Journal:  J Nucl Med       Date:  1982-03       Impact factor: 10.057

10.  Mitochondrial encephalomyopathy: fluctuating symptoms and CT.

Authors:  T Yamamoto; H Beppu; T Tsubaki
Journal:  Neurology       Date:  1984-11       Impact factor: 9.910
  10 in total
  1 in total

1.  Neuroradiological features of six kindreds with MELAS tRNA(Leu) A2343G point mutation: implications for pathogenesis.

Authors:  C M Sue; D S Crimmins; Y S Soo; R Pamphlett; C M Presgrave; N Kotsimbos; M J Jean-Francois; E Byrne; J G Morris
Journal:  J Neurol Neurosurg Psychiatry       Date:  1998-08       Impact factor: 10.154
  1 in total

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