| Literature DB >> 26368348 |
Nicholas A Isley1, Roscoe T H Linstadt1, Sean M Kelly1, Fabrice Gallou2, Bruce H Lipshutz1.
Abstract
Given the huge dependence on dipolar, aprotic solvents such as DMF, DMSO, DMAc, and NMP in nucleophilic aromatic substitution reactions (SNAr), a simple and environmentally friendly alternative is reported. Use of a "benign-by-design" nonionic surfactant, TPGS-750-M, in water enables nitrogen, oxygen, and sulfur nucleophiles to participate in SNAr reactions. Aromatic and heteroaromatic substrates readily participate in this micellar catalysis, which takes place at or near ambient temperatures.Entities:
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Year: 2015 PMID： 26368348 DOI： 10.1021/acs.orglett.5b02240
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005