Literature DB >> 26368132

Heat-Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET.

Marc D Normandin1, Hushan Yuan1, Moses Q Wilks1, Howard H Chen2, Joseph M Kinsella3, Hoonsung Cho4, Nicolas J Guehl1, Nader Absi-Halabi1, Seyed Mohammadreza Hosseini1, Georges El Fakhri1, David E Sosnovik2, Lee Josephson5,6.   

Abstract

Heat-induced radiolabeling (HIR) yielded (89) Zr-Feraheme (FH) nanoparticles (NPs) that were used to determine NP pharmacokinetics (PK) by positron emission tomography (PET). Standard uptake values indicated a fast hepatic uptake that corresponded to blood clearance, and a second, slow uptake process by lymph nodes and spleen. By cytometry, NPs were internalized by circulating monocytes and monocytes in vitro. Using an IV injection of HIR (89) Zr-FH (rather than in vitro cell labeling), PET/PK provided a view of monocyte trafficking, a key component of the immune response.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  heat-induced radiolabeling; imaging; monocyte trafficking; nanoparticles; pharmacokinetics; positron emission tomography

Mesh：

Substances：

Year:  2015        PMID： 26368132      PMCID： PMC4754124          DOI： 10.1002/anie.201505525

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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