Ignacio García-Doval1,2, Beatriz Pérez-Zafrilla1,3, Carlos Ferrandiz4, Gregorio Carretero5, Esteban Daudén6, Pablo de la Cueva7, Francisco J Gómez-García8, Enrique Herrera-Ceballos9, Isabel Belinchón-Romero10, Jose Luis Sánchez-Carazo11, Jose-Luis López-Estebaranz12, Merce Alsina13, Marta Ferrán14, Rosa Torrado5, Jose-Manuel Carrascosa4, Raquel Rivera15, Francisco Vanaclocha15. 1. a Research Unit , Fundación Academia Española de Dermatología y Venereología , Madrid , Spain . 2. b Department of Dermatology , Complexo Hospitalario Universitario de Vigo , Vigo , Spain . 3. c Research Unit , Complejo Hospitalario Universitario de Albacete , Albacete , Spain . 4. d Department of Dermatology , Hospital Universitario Germans Trias i Pujol, Badalona, Universitat Autónoma de Barcelona , Spain . 5. e Department of Dermatology , Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria , Spain . 6. f Department of Dermatology , Hospital Universitario La Princesa , Madrid , Spain . 7. g Department of Dermatology , Hospital Infanta Leonor , Madrid , Spain . 8. h Department of Dermatology , Hospital Universitario Reina Sofía , Córdoba , Spain . 9. i Department of Dermatology , Hospital Universitario Virgen de la Victoria , Málaga , Spain . 10. j Department of Dermatology , Hospital General Universitario de Alicante , Alicante , Spain . 11. k Department of Dermatology , Hospital General Universitario de Valencia , Valencia , Spain . 12. l Department of Dermatology , Hospital Universitario Fundación Alcorcón , Madrid , Spain . 13. m Department of Dermatology , Hospital Universitario Clinic de Barcelona , Barcelona , Spain . 14. n Department of Dermatology , Hospital del Mar, Parc de Salut Mar , Barcelona , Spain , and. 15. o Department of Dermatology , Hospital Universitario 12 de Octubre , Madrid , Spain.
Abstract
BACKGROUND: Identifying patients likely to have very good or bad results from systemic psoriasis therapy could improve efficiency of therapy. OBJECTIVE: To develop prognostic models for good or bad response to classic systemic drugs, anti-TNFs, and ustekinumab in psoriasis. METHODS: Multivariable logistic regression of a prospective multicenter cohort of psoriatic patients in clinical practice (6449 person-years of follow-up). We used as possible predictors demographic characteristics, comorbidities, characteristics of the psoriasis (type, PASI, arthritis), history of past therapy at entry in the cohort, and history of response to previous cycles while in the cohort. We defined good response to a treatment cycle as either cycle end due to disease remission or a cycle longer than 2 years that does not end later due to inefficacy in the follow-up period. Bad response to a treatment cycle was defined as a cycle that is finished due to inefficacy, based on the physician judgment, after more than 3 months of treatment. RESULTS: Patients with fewer previous therapies, lower body mass index, older at start of therapy, and with previous history of good responses to therapy are more likely to have positive results of therapy. However, the predictive characteristics of models are poor. CONCLUSION: Predictive models of clinical response to systemic drugs in psoriasis with the studied variables do not seem to outperform drug selection by a dermatologist.
BACKGROUND: Identifying patients likely to have very good or bad results from systemic psoriasis therapy could improve efficiency of therapy. OBJECTIVE: To develop prognostic models for good or bad response to classic systemic drugs, anti-TNFs, and ustekinumab in psoriasis. METHODS: Multivariable logistic regression of a prospective multicenter cohort of psoriaticpatients in clinical practice (6449 person-years of follow-up). We used as possible predictors demographic characteristics, comorbidities, characteristics of the psoriasis (type, PASI, arthritis), history of past therapy at entry in the cohort, and history of response to previous cycles while in the cohort. We defined good response to a treatment cycle as either cycle end due to disease remission or a cycle longer than 2 years that does not end later due to inefficacy in the follow-up period. Bad response to a treatment cycle was defined as a cycle that is finished due to inefficacy, based on the physician judgment, after more than 3 months of treatment. RESULTS:Patients with fewer previous therapies, lower body mass index, older at start of therapy, and with previous history of good responses to therapy are more likely to have positive results of therapy. However, the predictive characteristics of models are poor. CONCLUSION: Predictive models of clinical response to systemic drugs in psoriasis with the studied variables do not seem to outperform drug selection by a dermatologist.
Authors: R B Warren; A Marsden; B Tomenson; K J Mason; M M Soliman; A D Burden; N J Reynolds; D Stocken; R Emsley; C E M Griffiths; C Smith Journal: Br J Dermatol Date: 2018-08-28 Impact factor: 9.302