Leah H Schinasi1, Anneclaire J De Roos2, Roberta M Ray3, Kerstin L Edlefsen4, Christine G Parks5, Barbara V Howard6, Jaymie R Meliker7, Matthew R Bonner8, Robert B Wallace9, Andrea Z LaCroix10. 1. Department of Environmental and Occupational Health, School of Public Health, Drexel University, Philadelphia, PA. Electronic address: lhs36@drexel.edu. 2. Department of Environmental and Occupational Health, School of Public Health, Drexel University, Philadelphia, PA. 3. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA. 4. Department of Laboratory Medicine, University of Washington, Seattle. 5. Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC. 6. Department of Field Studies, MedStar Research Institute, Hyattsville, MD; Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC. 7. Department of Preventative Medicine and Graduate Program in Public Health, Stony Brook University, Stony Brook, NY. 8. Department of Epidemiology and Environmental Health, State University of New York at Buffalo, Buffalo. 9. Department of Epidemiology, University of Iowa College of Public Health, Iowa City. 10. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; Division of Epidemiology, School of Medicine, University of California San Diego, San Diego.
Abstract
PURPOSE: Relationships of farm history and insecticide exposure at home or work with lymphohematopoietic (LH) neoplasm risk were investigated in a large prospective cohort of US women. METHODS: In questionnaires, women self-reported history living or working on a farm, personally mixing or applying insecticides, insecticide application in the home or workplace by a commercial service, and treating pets with insecticides. Relationships with non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, plasma cell neoplasms, and myeloid leukemia were investigated using Cox proportional hazard models. Age and farming history were explored as effect modifiers. RESULTS: The analysis included 76,493 women and 822 NHL cases. Women who ever lived or worked on a farm had 1.12 times the risk of NHL (95% confidence interval [CI] = 0.95-1.32) compared to those who did not. Women who reported that a commercial service ever applied insecticides in their immediate surroundings had 65% higher risk of CLL/SLL (95% CI = 1.15-2.38). Women aged less than 65 years who ever applied insecticides had 87% higher risk of DLBCL (95% CI = 1.13-3.09). CONCLUSIONS: Insecticide exposures may contribute to risk of CLL/SLL and DLBCL. Future studies should examine relationships of LH subtypes with specific types of household insecticides.
PURPOSE: Relationships of farm history and insecticide exposure at home or work with lymphohematopoietic (LH) neoplasm risk were investigated in a large prospective cohort of US women. METHODS: In questionnaires, women self-reported history living or working on a farm, personally mixing or applying insecticides, insecticide application in the home or workplace by a commercial service, and treating pets with insecticides. Relationships with non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, plasma cell neoplasms, and myeloid leukemia were investigated using Cox proportional hazard models. Age and farming history were explored as effect modifiers. RESULTS: The analysis included 76,493 women and 822 NHL cases. Women who ever lived or worked on a farm had 1.12 times the risk of NHL (95% confidence interval [CI] = 0.95-1.32) compared to those who did not. Women who reported that a commercial service ever applied insecticides in their immediate surroundings had 65% higher risk of CLL/SLL (95% CI = 1.15-2.38). Women aged less than 65 years who ever applied insecticides had 87% higher risk of DLBCL (95% CI = 1.13-3.09). CONCLUSIONS: Insecticide exposures may contribute to risk of CLL/SLL and DLBCL. Future studies should examine relationships of LH subtypes with specific types of household insecticides.
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