OBJECTIVE: To evaluate myo-inositol concentrations in amniotic fluid in women later developing gestational diabetes and hypertension. METHODS: A retrospective study was carried out with three groups of amniotic fluid samples (15-18 gestational weeks): 30 gestational hypertension pregnancies, 30 gestational diabetes pregnancies, and 30 normal pregnancy. RESULTS: A significant difference was observed in myo-inositol concentrations between the median gestational diabetes values (124.0 µmol/L, IQR 90.0-162.5) and the control group values (79.0 µmol/L, IQR 62.0-107.5), but also with gestational hypertension median values (79.0 µmol/L, IQR 67.75-92.0) (p < 0.001). CONCLUSIONS: This study has shown that myo-inositol concentrations in amniotic fluid increased significantly in women later developing gestational diabetes compared to the control group.
OBJECTIVE: To evaluate myo-inositol concentrations in amniotic fluid in women later developing gestational diabetes and hypertension. METHODS: A retrospective study was carried out with three groups of amniotic fluid samples (15-18 gestational weeks): 30 gestational hypertension pregnancies, 30 gestational diabetes pregnancies, and 30 normal pregnancy. RESULTS: A significant difference was observed in myo-inositol concentrations between the median gestational diabetes values (124.0 µmol/L, IQR 90.0-162.5) and the control group values (79.0 µmol/L, IQR 62.0-107.5), but also with gestational hypertension median values (79.0 µmol/L, IQR 67.75-92.0) (p < 0.001). CONCLUSIONS: This study has shown that myo-inositol concentrations in amniotic fluid increased significantly in women later developing gestational diabetes compared to the control group.
Authors: Reshma A Pillai; Mohammed O Islam; Preben Selvam; Neha Sharma; Anne H Y Chu; Oliver C Watkins; Keith M Godfrey; Rohan M Lewis; Shiao Y Chan Journal: J Clin Endocrinol Metab Date: 2021-01-23 Impact factor: 5.958