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Literature DB >> 26364617

The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin.

G Grasso¹, V Lanza, G Malgieri, R Fattorusso, A Pietropaolo, E Rizzarelli, D Milardi.

Abstract

We report an ATP-dependent ubiquitin conjugation with IDE which, in turn, promotes Ub-Ub linkages in tube tests. We propose a novel function for IDE as a non-canonical ubiquitin activating enzyme.

Entities: Chemical Gene

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Substances：

Year: 2015 PMID： 26364617 DOI： 10.1039/c5cc06786c

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

7 in total

1. The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S.

Authors: Diego Sbardella; Grazia R Tundo; Andrea Coletta; Julien Marcoux; Efthymia Ioanna Koufogeorgou; Chiara Ciaccio; Anna M Santoro; Danilo Milardi; Giuseppe Grasso; Paola Cozza; Marie-Pierre Bousquet-Dubouch; Stefano Marini; Massimo Coletta
Journal: Cell Mol Life Sci Date: 2018-03-28 Impact factor: 9.261

Review 2. Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?

Authors: Laetitia Lesire; Florence Leroux; Rebecca Deprez-Poulain; Benoit Deprez
Journal: Cells Date: 2022-04-05 Impact factor: 6.600

3. The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor.

Authors: Giuseppe Pandini; Cristina Satriano; Adriana Pietropaolo; Fiorenza Gianì; Alessio Travaglia; Diego La Mendola; Vincenzo G Nicoletti; Enrico Rizzarelli
Journal: Front Neurosci Date: 2016-12-20 Impact factor: 4.677

4. Commentary on Ivancic et al.: Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme.

Authors: Giuseppe Grasso
Journal: Biosci Rep Date: 2018-11-28 Impact factor: 3.840

The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin.

1. The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S.

Review 2. Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?

3. The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor.

4. Commentary on Ivancic et al.: Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme.

5. The insulin-degrading enzyme as a link between insulin and neuropeptides metabolism.

6. Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme.

7. IDE Degrades Nociceptin/Orphanin FQ through an Insulin Regulated Mechanism.