Shuo Zhao1, Tingjun Chen2, Chunxia Peng2, Huanfen Zhou2, Hongyang Li2, Dehui Huang3, Quangang Xu4, Shihui Wei5. 1. Department of Neuro-Ophthalmology, The Chinese People's Liberation Army General Hospital, Beijing, China; Medical School of Nankai University, Tianjin, China. 2. Department of Neuro-Ophthalmology, The Chinese People's Liberation Army General Hospital, Beijing, China. 3. Department of Neurology, The Chinese People's Liberation Army General Hospital, Beijing, China. 4. Department of Neuro-Ophthalmology, The Chinese People's Liberation Army General Hospital, Beijing, China. Electronic address: xuquangang@126.com. 5. Department of Neuro-Ophthalmology, The Chinese People's Liberation Army General Hospital, Beijing, China. Electronic address: dr_weishihui@163.com.
Abstract
PURPOSE: To review the clinical features of optic neuritis (ON) combined with chronic hepatitis B (CHB) retrospectively. METHOD: Clinical data were reviewed for hospitalized patients diagnosed with isolated ON combined with chronic hepatitis B (CHB-ON) in the Chinese People's Liberation Army General Hospital. The ON diagnosis was confirmed following the criteria of the Optic Neuritis Treatment Trial (ONTT) group. The diagnostic criteria for CHB was serological positivity for hepatitis B surface antigen (HBsAg) for more than 6 months. Other infectious conditions that might lead to bias were excluded. RESULTS: A total of 13 patients (6 female and 7 male, 23 involved eyes) diagnosed with CHB-ON were selected. A total of 12/13 patients presented as atypical ON: 10/13 of the patients exhibited simultaneous or early sequential bilateral eye involvement; 11/13 involved eyes in the acute phase presented with pronounced optic disc edema; and 11/13 patients exhibited corticosteroid resistant. A total of 12/23 affected eyes suffered severe vision loss (<20/200) at the end of the follow-up period, which averaged 13.7 (4-31) months. None of the patients progressed to multiple sclerosis (MS) or neuromyelitis optica (NMO). All blood samples were negative for serological aquaporin 4-antibody using the cell-based assay. CONCLUSIONS: CHB-ON usually presented as the atypical form. Chronic hepatitis B virus infection may lead to the tendency for ON exacerbation.
PURPOSE: To review the clinical features of optic neuritis (ON) combined with chronic hepatitis B (CHB) retrospectively. METHOD: Clinical data were reviewed for hospitalized patients diagnosed with isolated ON combined with chronic hepatitis B (CHB-ON) in the Chinese People's Liberation Army General Hospital. The ON diagnosis was confirmed following the criteria of the Optic Neuritis Treatment Trial (ONTT) group. The diagnostic criteria for CHB was serological positivity for hepatitis B surface antigen (HBsAg) for more than 6 months. Other infectious conditions that might lead to bias were excluded. RESULTS: A total of 13 patients (6 female and 7 male, 23 involved eyes) diagnosed with CHB-ON were selected. A total of 12/13 patients presented as atypical ON: 10/13 of the patients exhibited simultaneous or early sequential bilateral eye involvement; 11/13 involved eyes in the acute phase presented with pronounced optic disc edema; and 11/13 patients exhibited corticosteroid resistant. A total of 12/23 affected eyes suffered severe vision loss (<20/200) at the end of the follow-up period, which averaged 13.7 (4-31) months. None of the patients progressed to multiple sclerosis (MS) or neuromyelitis optica (NMO). All blood samples were negative for serological aquaporin 4-antibody using the cell-based assay. CONCLUSIONS: CHB-ON usually presented as the atypical form. Chronic hepatitis B virus infection may lead to the tendency for ON exacerbation.