| Literature DB >> 26363896 |
Paolo Fagone1, Ferdinando Nicoletti1, Lucia Salvatorelli2, Giuseppe Musumeci3, Gaetano Magro4.
Abstract
Recent immunohistochemical analyses have showed that cyclin D1 is expressed in soft tissue Ewing's sarcoma/peripheral neuroectodermal tumor (PNET) of childhood and adolescents, while it is undetectable in both embryonal and alveolar rhabdomyosarcoma. In the present paper, microarray analysis provided evidence of a significant upregulation of cyclin D1 in Ewing's sarcoma as compared to normal tissues. In addition, we confirmed our previous findings of a significant over-expression of cyclin D1 in Ewing sarcoma as compared to rhabdomyosarcoma. Bioinformatic analysis also allowed to identify some other genes, strongly correlated to cyclin D1, which, although not previously studied in pediatric tumors, could represent novel markers for the diagnosis and prognosis of Ewing's sarcoma/PNET. The data herein provided support not only the use of cyclin D1 as a diagnostic marker of Ewing sarcoma/PNET but also the possibility of using drugs targeting cyclin D1 as potential therapeutic strategies.Entities:
Keywords: Bioinformatic analysis; Cyclin D1; Ewing's sarcoma/peripheral primitive neuroectodermal tumor; Microarray; Rhabdomyosarcoma
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Year: 2015 PMID： 26363896 DOI： 10.1016/j.acthis.2015.08.006
Source DB: PubMed Journal: Acta Histochem ISSN： 0065-1281 Impact factor: 2.479