Güliz Kozdağ1, İrem Yaluğ2, Nagihan İnan3, Gökhan Ertaş4, Macit Selekler5, Hüseyin Kutlu2, Ayşe Kutlu5, Ender Emre1, Metin Çetin6, Dilek Ural1. 1. Department of Cardiology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey. 2. Department of Psychiatry, Kocaeli University Faculty of Medicine, Kocaeli, Turkey. 3. Department of Radiology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey. 4. Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey. 5. Department of Neurology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey. 6. Department of Cardiology, Central Hospital, Kocaeli, Turkey.
Abstract
OBJECTIVE: Depression frequently occurs in patients with heart failure as similar pathophysiological mechanisms present in both these diseases. Patients with dilated cardiomyopathy (DCM) have a high incidence of clinically asymptomatic silent cerebral infarction (SCI). This study aimed to evaluate the relation between SCI and major depressive disorder (MDD), and between MDD and clinical and biochemical parameters in DCM patients. METHODS: Patients with ischemic and non-ischemic DCM who had chronic heart failure (CHF) (39 male, 10 female, age 60±10 years) were included in the study. Mean patient ejection fraction (EF) was 34±10%. Patients had no localized neurological symptoms or stroke history. The etiology of DCM was ischemic in 40 and non-ischemic in 9 patients. Twenty-five age-matched healthy volunteers served as a control group for comparison of SCI and MDD prevalence. RESULTS: Patients had mild to severe CHF symptoms. Prevalence of SCI and MDD was significantly higher in patients with DCM than in the control group; 63% vs 8%; p<0.001, and 52% vs 20%; p<0.001 respectively. Patients with SCI had a higher prevalence of MDD than patients without SCI in DCM (61% vs 27%, p=0.02). CONCLUSION: CHF patients have an increased prevalence of SCI and MDD. Patients with SCI have a higher prevalence of MDD compared to patients without SCI in CHF.
OBJECTIVE:Depression frequently occurs in patients with heart failure as similar pathophysiological mechanisms present in both these diseases. Patients with dilated cardiomyopathy (DCM) have a high incidence of clinically asymptomatic silent cerebral infarction (SCI). This study aimed to evaluate the relation between SCI and major depressive disorder (MDD), and between MDD and clinical and biochemical parameters in DCMpatients. METHODS:Patients with ischemic and non-ischemicDCM who had chronic heart failure (CHF) (39 male, 10 female, age 60±10 years) were included in the study. Mean patient ejection fraction (EF) was 34±10%. Patients had no localized neurological symptoms or stroke history. The etiology of DCM was ischemic in 40 and non-ischemic in 9 patients. Twenty-five age-matched healthy volunteers served as a control group for comparison of SCI and MDD prevalence. RESULTS:Patients had mild to severe CHF symptoms. Prevalence of SCI and MDD was significantly higher in patients with DCM than in the control group; 63% vs 8%; p<0.001, and 52% vs 20%; p<0.001 respectively. Patients with SCI had a higher prevalence of MDD than patients without SCI in DCM (61% vs 27%, p=0.02). CONCLUSION:CHFpatients have an increased prevalence of SCI and MDD. Patients with SCI have a higher prevalence of MDD compared to patients without SCI in CHF.
Authors: Howard J Aizenstein; Andrius Baskys; Maura Boldrini; Meryl A Butters; Breno S Diniz; Manoj Kumar Jaiswal; Kurt A Jellinger; Lev S Kruglov; Ivan A Meshandin; Milija D Mijajlovic; Guenter Niklewski; Sarah Pospos; Keerthy Raju; Kneginja Richter; David C Steffens; Warren D Taylor; Oren Tene Journal: BMC Med Date: 2016-11-03 Impact factor: 8.775