Literature DB >> 26363542

Multiple Endocrine Neoplasia: Genetics and Clinical Management.

Jeffrey A Norton1, Geoffrey Krampitz2, Robert T Jensen3.   

Abstract

Early diagnosis of multiple endocrine neoplasia (MEN) syndromes is critical for optimal clinical outcomes; before the MEN syndromes can be diagnosed, they must be suspected. Genetic testing for germline alterations in both the MEN type 1 (MEN1) gene and RET proto-oncogene is crucial to identifying those at risk in affected kindreds and directing timely surveillance and surgical therapy to those at greatest risk of potentially life-threatening neoplasia. Pancreatic, thymic, and bronchial neuroendocrine tumors are the leading cause of death in patients with MEN1 and should be aggressively considered by at least biannual computed tomography imaging.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Clinical management; Endocrine neoplasia; Genetics; Multiple endocrine neoplasia

Mesh：

Year:  2015        PMID： 26363542      PMCID： PMC4571281          DOI： 10.1016/j.soc.2015.06.008

Source DB:  PubMed          Journal:  Surg Oncol Clin N Am        ISSN： 1055-3207            Impact factor:   3.495


  231 in total

1.  ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary.

Authors:  Marianne Pavel; Eric Baudin; Anne Couvelard; Eric Krenning; Kjell Öberg; Thomas Steinmüller; Martin Anlauf; Bertram Wiedenmann; Ramon Salazar
Journal:  Neuroendocrinology       Date:  2012-02-15       Impact factor: 4.914

2.  Sympathoadrenal hyperplasia causes renal malformations in Ret(MEN2B)-transgenic mice.

Authors:  C Gestblom; D A Sweetser; B Doggett; R P Kapur
Journal:  Am J Pathol       Date:  1999-12       Impact factor: 4.307

3.  A randomized, prospective trial of operative treatments for hyperparathyroidism in patients with multiple endocrine neoplasia type 1.

Authors:  Terry C Lairmore; Cara M Govednik; Courtney E Quinn; Benjamin R Sigmond; Cortney Y Lee; Daniel C Jupiter
Journal:  Surgery       Date:  2014-09-26       Impact factor: 3.982

4.  Liver metastases of endocrine tumour associated with multiple endocrine neoplasia type 1: a sustained response to interferon therapy or a peculiar benign course?

Authors:  A Grieco; A Bianco; B Alfei; V Rufini; F M Vecchio; S Marcoccia; G Gasbarrini
Journal:  Hepatogastroenterology       Date:  2000 Sep-Oct

5.  Study of a kindred with pheochromocytoma, medullary thyroid carcinoma, hyperparathyroidism and Cushing's disease: multiple endocrine neoplasia, type 2.

Authors:  A L Steiner; A D Goodman; S R Powers
Journal:  Medicine (Baltimore)       Date:  1968-09       Impact factor: 1.889

6.  Comparison of surgical results in patients with advanced and limited disease with multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome.

Authors:  J A Norton; H R Alexander; D L Fraker; D J Venzon; F Gibril; R T Jensen
Journal:  Ann Surg       Date:  2001-10       Impact factor: 12.969

7.  MEN1 disease occurring before 21 years old: a 160-patient cohort study from the Groupe d'étude des Tumeurs Endocrines.

Authors:  P Goudet; A Dalac; M Le Bras; C Cardot-Bauters; P Niccoli; N Lévy-Bohbot; H du Boullay; X Bertagna; P Ruszniewski; F Borson-Chazot; B Vergès; J L Sadoul; F Ménégaux; A Tabarin; J M Kühn; P d'Anella; O Chabre; S Christin-Maitre; G Cadiot; C Binquet; B Delemer
Journal:  J Clin Endocrinol Metab       Date:  2015-01-16       Impact factor: 5.958

8.  Screening of patients with multiple endocrine neoplasia type 1 (MEN-1): a critical analysis of its value.

Authors:  Jens Waldmann; Volker Fendrich; Nils Habbe; Detlef K Bartsch; Emily P Slater; Peter H Kann; Matthias Rothmund; Peter Langer
Journal:  World J Surg       Date:  2009-06       Impact factor: 3.352

9.  Thymic carcinoids in multiple endocrine neoplasia type 1.

Authors:  B T Teh; J Zedenius; S Kytölä; B Skogseid; J Trotter; H Choplin; S Twigg; F Farnebo; S Giraud; D Cameron; B Robinson; A Calender; C Larsson; P Salmela
Journal:  Ann Surg       Date:  1998-07       Impact factor: 12.969

10.  Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development.

Authors:  A Schuchardt; V D'Agati; V Pachnis; F Costantini
Journal:  Development       Date:  1996-06       Impact factor: 6.868
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  23 in total

Review 1.  Clinical aspects of multiple endocrine neoplasia type 1.

Authors:  Abdallah Al-Salameh; Guillaume Cadiot; Alain Calender; Pierre Goudet; Philippe Chanson
Journal:  Nat Rev Endocrinol       Date:  2021-02-09       Impact factor: 43.330

2.  Treatment of Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1: Some Clarity But Continued Controversy.

Authors:  Robert T Jensen; Jeffrey A Norton
Journal:  Pancreas       Date:  2017 May/Jun       Impact factor: 3.327

Review 3.  Gastrinomas: Medical or Surgical Treatment.

Authors:  Jeffrey A Norton; Deshka S Foster; Tetsuhide Ito; Robert T Jensen
Journal:  Endocrinol Metab Clin North Am       Date:  2018-09       Impact factor: 4.741

4.  Long Noncoding RNA MEG3 Is an Epigenetic Determinant of Oncogenic Signaling in Functional Pancreatic Neuroendocrine Tumor Cells.

Authors:  Sucharitha Iyer; Sita D Modali; Sunita K Agarwal
Journal:  Mol Cell Biol       Date:  2017-10-27       Impact factor: 4.272

Review 5.  A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology.

Authors:  Laurent Ehrlich; Chad Hall; Fanyin Meng; Terry Lairmore; Gianfranco Alpini; Shannon Glaser
Journal:  Gene Expr       Date:  2017-04-28

6.  Diagnosis of Zollinger-Ellison syndrome in the era of PPIs, faulty gastrin assays, sensitive imaging and limited access to acid secretory testing.

Authors:  David C Metz; Guillaume Cadiot; Pierre Poitras; Tetsuhide Ito; Robert T Jensen
Journal:  Int J Endocr Oncol       Date:  2017-10-11

Review 7.  Endocrine neoplasms in familial syndromes of hyperparathyroidism.

Authors:  Yulong Li; William F Simonds
Journal:  Endocr Relat Cancer       Date:  2016-05-20       Impact factor: 5.678

Review 8.  [Syndromic Hirschsprung′s disease and its mode of inheritance].

Authors:  Jing-Ru Zhang; Zhi-Bo Zhang
Journal:  Zhongguo Dang Dai Er Ke Za Zhi       Date:  2018-05

9.  Timely diagnosis of multiple endocrine neoplasia 2B by identification of intestinal ganglioneuromatosis: a case series.

Authors:  Medard F M van den Broek; Ester B G Rijks; Peter G J Nikkels; Victorien M Wolters; Robert J J van Es; Hanneke M van Santen; Bernadette P M van Nesselrooij; Menno R Vriens; Rachel S van Leeuwaarde; Gerlof D Valk; Annemarie A Verrijn Stuart
Journal:  Endocrine       Date:  2021-01-21       Impact factor: 3.633

Review 10.  A narrative review of multiple endocrine neoplasia syndromes: genetics, clinical features, imaging findings, and diagnosis.

Authors:  Xuefang Hu; Jian Guan; Yangdi Wang; Siya Shi; Chenyu Song; Zi-Ping Li; Shi-Ting Feng; Jie Chen; Yanji Luo
Journal:  Ann Transl Med       Date:  2021-06
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