Effects of the terbuthylazine metabolite terbuthylazine-desethyl on common carp embryos and larvae.

Toxicity of terbuthylazine-desethyl to embryos and larvae of common carp (Cyprinus carpio) was assessed. Based on mortality, the lethal concentration of terbuthylazine-desethyl was estimated to be 31days LC50=441.6μg/L. Carp exposed to terbuthylazine-desethyl at 1800μg/L exhibited lower weight and length at 7days of exposure compared to the control group. By day 20, carp exposed to 900μg/L terbuthylazine-desethyl showed lower weight and length compared to control group. Terbuthylazine-desethyl in concentrations (180, 900, and 1800μg/L) caused delay in ontogenetic development. Total superoxide dismutase activity was significantly lower in all exposed groups. Exposure to 180 and 900μg/L terbuthylazine-desethyl was associated with alteration of the caudal kidney tubular system including peritubular dilatation detachment of epithelial cells from the basal lamina, and focal autolytic disintegration of the tubular epithelia. Chronic terbuthylazine-desethyl exposure affected survival, growth, ontogenetic development, and the antioxidant system and caused pathological changes to the caudal kidney.