Matjaž Homan1, Dora Mahkovic1, Rok Orel1, Petar Mamula2. 1. The Children's Hospital, University Medical Centre of Ljubljana, Ljubljana, Slovenia. 2. The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Abstract
BACKGROUND AND AIMS: Studies in adults have shown that postprocedural abdominal pain is reduced with the use of carbon dioxide (CO(2)) instead of air for insufflation during colonoscopy. The aim of our study was to compare postprocedural abdominal pain and girth in children undergoing colonoscopy using CO(2) or air for insufflation. METHODS: This was a prospective, randomized, double-blind study that included 76 consecutive pediatric patients undergoing colonoscopy for various indications. Patients were randomly assigned to either CO(2) or air insufflation. At 2, 4, and 24 hours after the examination, the patients' pain was assessed by using the 11-point numerical rating scale. The waist circumference was measured 10 minutes and 2 and 4 hours after colonoscopy. RESULTS: A significantly higher proportion of patients had no pain after colonoscopy in the CO(2) group compared with the air group (82 vs 37% at 2 hours and 95% vs. 63% at 4 hours, P < .001). Mean abdominal pain scores 2 and 4 hours after the procedure were statistically significantly lower in the CO(2) group compared with the control air group (0.5 vs 2.6 at 2 hours and 0.1 vs 1.2 at 4 hours, P < .001). There was no difference in waist circumference between the 2 groups at all time intervals. CONCLUSION: The results of this randomized trial show clear benefits of CO(2) insufflation for colonoscopy in reducing postprocedural discomfort. ( CLINICAL TRIAL REGISTRATION NUMBER: NCT02407639.).
RCT Entities:
BACKGROUND AND AIMS: Studies in adults have shown that postprocedural abdominal pain is reduced with the use of carbon dioxide (CO(2)) instead of air for insufflation during colonoscopy. The aim of our study was to compare postprocedural abdominal pain and girth in children undergoing colonoscopy using CO(2) or air for insufflation. METHODS: This was a prospective, randomized, double-blind study that included 76 consecutive pediatric patients undergoing colonoscopy for various indications. Patients were randomly assigned to either CO(2) or air insufflation. At 2, 4, and 24 hours after the examination, the patients' pain was assessed by using the 11-point numerical rating scale. The waist circumference was measured 10 minutes and 2 and 4 hours after colonoscopy. RESULTS: A significantly higher proportion of patients had no pain after colonoscopy in the CO(2) group compared with the air group (82 vs 37% at 2 hours and 95% vs. 63% at 4 hours, P < .001). Mean abdominal pain scores 2 and 4 hours after the procedure were statistically significantly lower in the CO(2) group compared with the control air group (0.5 vs 2.6 at 2 hours and 0.1 vs 1.2 at 4 hours, P < .001). There was no difference in waist circumference between the 2 groups at all time intervals. CONCLUSION: The results of this randomized trial show clear benefits of CO(2) insufflation for colonoscopy in reducing postprocedural discomfort. ( CLINICAL TRIAL REGISTRATION NUMBER: NCT02407639.).
Authors: John Alexander Lata Guacho; Diogo Turiani Hourneaux de Moura; Igor Braga Ribeiro; Bruna Furia Buzetti Hourneaux de Moura; Megui Marilia Mansilla Gallegos; Thomas McCarty; Ricardo Katsuya Toma; Eduardo Guimarães Hourneaux de Moura Journal: Clin Endosc Date: 2021-03-25
Authors: Su Young Kim; Jun-Won Chung; Jung Ho Kim; Yoon Jae Kim; Kyoung Oh Kim; Kwang An Kwon; Dong Kyun Park Journal: United European Gastroenterol J Date: 2018-05-04 Impact factor: 4.623