Literature DB >> 26363200

Acetaminophen hepatotoxicity and sterile inflammation: The mechanism of protection of Chlorogenic acid.

Hartmut Jaeschke1.   

Abstract

Acetaminophen hepatotoxicity is characterized by extensive necrotic cell death and a sterile inflammatory response. A recent report suggested that a therapeutic intervention with chlorogenic acid, a dietary polyphenolic compound, protects against acetaminophen-induced liver injury by inhibiting the inflammatory injury. The purpose of this letter is to discuss a number of reasons why the protective mechanism of chlorogenic acid against acetaminophen hepatotoxicity does not involve an anti-inflammatory effect and provides an alternative explanation for the observed protection.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Acetaminophen hepatotoxicity; Natural products; Neutrophils; Sterile inflammation

Mesh：

Substances：

Year:  2015        PMID： 26363200      PMCID： PMC4872296          DOI： 10.1016/j.cbi.2015.08.025

Source DB:  PubMed          Journal:  Chem Biol Interact        ISSN： 0009-2797            Impact factor:   5.192


  10 in total

1.  Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice.

Authors:  Clarence David Williams; Mary Lynn Bajt; Anwar Farhood; Hartmut Jaeschke
Journal:  Liver Int       Date:  2010-10       Impact factor: 5.828

Review 2.  Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning.

Authors:  Hartmut Jaeschke
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2003-01       Impact factor: 4.052

Review 3.  Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions.

Authors:  Hartmut Jaeschke
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2006-06       Impact factor: 4.052

4.  Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans.

Authors:  C David Williams; Mary Lynn Bajt; Matthew R Sharpe; Mitchell R McGill; Anwar Farhood; Hartmut Jaeschke
Journal:  Toxicol Appl Pharmacol       Date:  2014-01-15       Impact factor: 4.219

Review 5.  Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity.

Authors:  Hartmut Jaeschke; C David Williams; Anup Ramachandran; Mary L Bajt
Journal:  Liver Int       Date:  2011-03-14       Impact factor: 5.828

6.  The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation.

Authors:  Zhiyong Zheng; Yuchen Sheng; Bing Lu; Lili Ji
Journal:  Chem Biol Interact       Date:  2015-06-12       Impact factor: 5.192

Review 7.  Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.

Authors:  Hartmut Jaeschke; Mitchell R McGill; Anup Ramachandran
Journal:  Drug Metab Rev       Date:  2012-01-10       Impact factor: 4.518

8.  Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice.

Authors:  Jaspreet S Gujral; Anwar Farhood; Mary Lynn Bajt; Hartmut Jaeschke
Journal:  Hepatology       Date:  2003-08       Impact factor: 17.425

9.  Inhibition of murine hepatic cytochrome P450 activities by natural and synthetic phenolic compounds.

Authors:  W Baer-Dubowska; H Szaefer; V Krajka-Kuzniak
Journal:  Xenobiotica       Date:  1998-08       Impact factor: 1.908

10.  Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.

Authors:  Mitchell R McGill; Margitta Lebofsky; Hye-Ryun K Norris; Matthew H Slawson; Mary Lynn Bajt; Yuchao Xie; C David Williams; Diana G Wilkins; Douglas E Rollins; Hartmut Jaeschke
Journal:  Toxicol Appl Pharmacol       Date:  2013-04-06       Impact factor: 4.219
  10 in total
  1 in total

1.  Chlorogenic Acid Alleviates Allergic Inflammatory Responses Through Regulating Th1/Th2 Balance in Ovalbumin-Induced Allergic Rhinitis Mice.

Authors:  Feilin Dong; Jun Tan; Yi Zheng
Journal:  Med Sci Monit       Date:  2020-09-01
  1 in total

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