Samuel Hoare1, Fiona Lithander2, Ingrid van der Mei3, Anne-Louise Ponsonby4, Robyn Lucas5. 1. National Centre for Epidemiology and Population Health, The Australian National University, Australia samuelhoare7@gmail.com. 2. The University of Canberra, Australia. 3. Menzies Institute for Medical Research, Australia. 4. Murdoch Childrens Research Institute, Royal Children's Hospital, University of Melbourne, Australia. 5. National Centre for Epidemiology and Population Health, The Australian National University, Australia.
Abstract
BACKGROUND: There is contradictory evidence for a role of dietary fat in risk of multiple sclerosis (MS). OBJECTIVES: To examine the association between usual fat intake (total, saturated, monounsaturated (MUFA), polyunsaturated (PUFA), omega-3 and omega-6) and risk of a first clinical diagnosis of CNS demyelination (FCD). METHODS: Multi-centre incident case-control study in four regions of Australia during 2003-2006. Cases were aged 18-59 years and had a FCD; controls were matched to a case on age, sex and location. Dietary data were collected using a validated food frequency questionnaire. RESULTS: In 267 cases and 517 controls with dietary data, higher intake (per g/day) of omega-3 PUFA (adjusted odds ratio, AOR=0.61 (95% CI 0.40-0.93)), and particularly that derived from fish (AOR=0.54 (95% CI 0.31-0.93)) rather than from plants (AOR=0.75 (95% CI 0.39-1.43)) was associated with a decreased risk of FCD. Total fat intake and intake of other types of fat were not associated with FCD risk. CONCLUSIONS: There was a significant decrease in FCD risk with higher intake of omega-3 PUFA, particularly that originating from fish. There was no evidence to indicate that the intake of other types of dietary fat or fat quantity in the previous 12 months was associated with an altered risk of FCD.
BACKGROUND: There is contradictory evidence for a role of dietary fat in risk of multiple sclerosis (MS). OBJECTIVES: To examine the association between usual fat intake (total, saturated, monounsaturated (MUFA), polyunsaturated (PUFA), omega-3 and omega-6) and risk of a first clinical diagnosis of CNS demyelination (FCD). METHODS: Multi-centre incident case-control study in four regions of Australia during 2003-2006. Cases were aged 18-59 years and had a FCD; controls were matched to a case on age, sex and location. Dietary data were collected using a validated food frequency questionnaire. RESULTS: In 267 cases and 517 controls with dietary data, higher intake (per g/day) of omega-3 PUFA (adjusted odds ratio, AOR=0.61 (95% CI 0.40-0.93)), and particularly that derived from fish (AOR=0.54 (95% CI 0.31-0.93)) rather than from plants (AOR=0.75 (95% CI 0.39-1.43)) was associated with a decreased risk of FCD. Total fat intake and intake of other types of fat were not associated with FCD risk. CONCLUSIONS: There was a significant decrease in FCD risk with higher intake of omega-3 PUFA, particularly that originating from fish. There was no evidence to indicate that the intake of other types of dietary fat or fat quantity in the previous 12 months was associated with an altered risk of FCD.
Authors: Dalia L Rotstein; Ruth Ann Marrie; Colleen Maxwell; Sima Gandhi; Susan E Schultz; Kinwah Fung; Karen Tu Journal: Neurology Date: 2019-11-05 Impact factor: 9.910
Authors: Julia Pakpoor; Brandon Seminatore; Jennifer S Graves; Teri Schreiner; Amy T Waldman; Timothy E Lotze; Anita Belman; Benjamin M Greenberg; Bianca Weinstock-Guttman; Gregory Aaen; Jan-Mendelt Tillema; Jamie C McDonald; Janace Hart; Jayne M Ness; Yolanda Harris; Jennifer Rubin; Meghan Candee; Lauren Krupp; Mark Gorman; Leslie Benson; Moses Rodriguez; Tanuja Chitnis; Soe Mar; Ilana Kahn; John Rose; Suzan L Carmichael; Shelly Roalstad; Michael Waltz; T Charles Casper; Emmanuelle Waubant Journal: Mult Scler Date: 2017-06-13 Impact factor: 6.312