Literature DB >> 26362152

Relationship of the Acoustic Startle Response and Its Modulation to Emotional and Behavioral Problems in Typical Development Children and Those with Autism Spectrum Disorders.

Hidetoshi Takahashi1,2, Sahoko Komatsu3, Takayuki Nakahachi3, Kazuo Ogino3, Yoko Kamio3.   

Abstract

Auditory hyper-reactivity is a common sensory-perceptual abnormality in autism spectrum disorders (ASD), which interrupts behavioral adaptation. We investigated acoustic startle response (ASR) modulations in 17 children with ASD and 27 with typical development (TD). Compared to TD, children with ASD had larger ASR magnitude to weak stimuli and more prolonged peak startle-latency. We could not find significant difference of prepulse inhibition (PPI) or habituation in ASD children compared to TD. However, habituation and PPI at 70-dB prepulses were negatively related to several subscales of Social Responsiveness Scale and the Strengths and Difficulties Questionnaire, when considering all children. Comprehensive investigation of ASR and its modulation might increase understanding of the neurophysiological impairments underlying ASD and other mental health problems in children.

Entities:  

Keywords:  Acoustic startle response; Autism spectrum disorders; Habituation; Prepulse inhibition; Sensory-motor gating; Startle latency

Mesh：

Year:  2016        PMID： 26362152     DOI： 10.1007/s10803-015-2593-4

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


  42 in total

1.  Maturation of prepulse inhibition (PPI) in childhood.

Authors:  J Gebhardt; S Schulz-Juergensen; P Eggert
Journal:  Psychophysiology       Date:  2011-12-16       Impact factor: 4.016

2.  Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects.

Authors:  Hidetoshi Takahashi; Masao Iwase; Leonides Canuet; Yuka Yasuda; Kazutaka Ohi; Motoyuki Fukumoto; Naomi Iike; Takayuki Nakahachi; Koji Ikezawa; Michiyo Azechi; Ryu Kurimoto; Ryouhei Ishii; Tetsuhiko Yoshida; Hiroaki Kazui; Ryota Hashimoto; Masatoshi Takeda
Journal:  Psychophysiology       Date:  2010-03-10       Impact factor: 4.016

3.  The Strengths and Difficulties Questionnaire: a research note.

Authors:  R Goodman
Journal:  J Child Psychol Psychiatry       Date:  1997-07       Impact factor: 8.982

4.  Enhanced pitch sensitivity in individuals with autism: a signal detection analysis.

Authors:  Anna Bonnel; Laurent Mottron; Isabelle Peretz; Manon Trudel; Erick Gallun; Anne-Marie Bonnel
Journal:  J Cogn Neurosci       Date:  2003-02-15       Impact factor: 3.225

Review 5.  From circuits to behaviour in the amygdala.

Authors:  Patricia H Janak; Kay M Tye
Journal:  Nature       Date:  2015-01-15       Impact factor: 49.962

6.  Autistic traits in the general population: a twin study.

Authors:  John N Constantino; Richard D Todd
Journal:  Arch Gen Psychiatry       Date:  2003-05

7.  Reduced neural habituation in the amygdala and social impairments in autism spectrum disorders.

Authors:  Natalia M Kleinhans; L Clark Johnson; Todd Richards; Roderick Mahurin; Jessica Greenson; Geraldine Dawson; Elizabeth Aylward
Journal:  Am J Psychiatry       Date:  2009-02-17       Impact factor: 18.112

8.  Amygdala habituation and prefrontal functional connectivity in youth with autism spectrum disorders.

Authors:  Johnna R Swartz; Jillian Lee Wiggins; Melisa Carrasco; Catherine Lord; Christopher S Monk
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  2012-12-02       Impact factor: 8.829

9.  Autism and pitch processing splinter skills: a group and subgroup analysis.

Authors:  Pamela Heaton; Kerry Williams; Omar Cummins; Francesca Happé
Journal:  Autism       Date:  2008-03

10.  Prepulse inhibition of startle response: recent advances in human studies of psychiatric disease.

Authors:  Hidetoshi Takahashi; Ryota Hashimoto; Masao Iwase; Ryouhei Ishii; Yoko Kamio; Masatoshi Takeda
Journal:  Clin Psychopharmacol Neurosci       Date:  2011-12-31       Impact factor: 2.582
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  14 in total

Review 1.  Sensory processing in autism spectrum disorders and Fragile X syndrome-From the clinic to animal models.

Authors:  D Sinclair; B Oranje; K A Razak; S J Siegel; S Schmid
Journal:  Neurosci Biobehav Rev       Date:  2016-05-24       Impact factor: 8.989

Review 2.  Critical reappraisal of mechanistic links of copy number variants to dimensional constructs of neuropsychiatric disorders in mouse models.

Authors:  Noboru Hiroi
Journal:  Psychiatry Clin Neurosci       Date:  2018-03-01       Impact factor: 5.188

3.  Altered Auditory Processing, Filtering, and Reactivity in the Cntnap2 Knock-Out Rat Model for Neurodevelopmental Disorders.

Authors:  Kaela E Scott; Ashley L Schormans; Katharine Y Pacoli; Cleusa De Oliveira; Brian L Allman; Susanne Schmid
Journal:  J Neurosci       Date:  2018-08-20       Impact factor: 6.167

4.  cacna2d3, a voltage-gated calcium channel subunit, functions in vertebrate habituation learning and the startle sensitivity threshold.

Authors:  Nicholas J Santistevan; Jessica C Nelson; Elelbin A Ortiz; Andrew H Miller; Dima Kenj Halabi; Zoë A Sippl; Michael Granato; Yevgenya Grinblat
Journal:  PLoS One       Date:  2022-07-14       Impact factor: 3.752

5.  Relationship between physiological and parent-observed auditory over-responsiveness in children with typical development and those with autism spectrum disorders.

Authors:  Hidetoshi Takahashi; Takayuki Nakahachi; Andrew Stickley; Makoto Ishitobi; Yoko Kamio
Journal:  Autism       Date:  2016-12-19

6.  Acoustic Hyper-Reactivity and Negatively Skewed Locomotor Activity in Children With Autism Spectrum Disorders: An Exploratory Study.

Authors:  Hidetoshi Takahashi; Toru Nakamura; Jinhyuk Kim; Hiroe Kikuchi; Takayuki Nakahachi; Makoto Ishitobi; Ken Ebishima; Kazuhiro Yoshiuchi; Tetsuya Ando; Andrew Stickley; Yoshiharu Yamamoto; Yoko Kamio
Journal:  Front Psychiatry       Date:  2018-08-06       Impact factor: 4.157

7.  Relationship of the Acoustic Startle Response and Its Modulation to Adaptive and Maladaptive Behaviors in Typically Developing Children and Those With Autism Spectrum Disorders: A Pilot Study.

Authors:  Ken Ebishima; Hidetoshi Takahashi; Andrew Stickley; Takayuki Nakahachi; Tomiki Sumiyoshi; Yoko Kamio
Journal:  Front Hum Neurosci       Date:  2019-01-22       Impact factor: 3.169

8.  Embryonic stem cell transplants as a therapeutic strategy in a rodent model of autism.

Authors:  Jennifer J Donegan; Angela M Boley; Daniel J Lodge
Journal:  Neuropsychopharmacology       Date:  2018-02-07       Impact factor: 7.853

9.  A Gene-Based Analysis of Acoustic Startle Latency.

Authors:  Alicia K Smith; Tanja Jovanovic; Varun Kilaru; Adriana Lori; Lauren Gensler; Samuel S Lee; Seth Davin Norrholm; Nicholas Massa; Bruce Cuthbert; Bekh Bradley; Kerry J Ressler; Erica Duncan
Journal:  Front Psychiatry       Date:  2017-07-06       Impact factor: 4.157

Review 10.  Neural Hyperexcitability in Autism Spectrum Disorders.

Authors:  Yukari Takarae; John Sweeney
Journal:  Brain Sci       Date:  2017-10-13
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