PURPOSE: Diabetes mellitus represents an increasing problem for patients and health care systems worldwide. We sought to investigate the effect of diabetes and its associated comorbidities on long-term survival and quality of life following an admission to a medical intensive care unit (ICU). METHODS: A total of 6662 consecutive patients admitted to ICU between 2004 and 2009 were included (patients with diabetes n=796, non-diabetic patients n=5866). The primary endpoint of the study was death of any cause. Data on mortality was collected upon review of medical records or phone interviews. Moreover, a questionnaire was sent to 500 randomly selected patients addressing Health related Quality of Life (HrQoL) after ICU treatment. RESULTS: Overall mortality did not differ significantly between diabetic and non-diabetic patients after ICU treatment (mean follow-up time: 490 days). For a subgroup of patients already exhibiting comorbidities associated with diabetes, the mortality rate was significantly higher (p=0.022). Regarding quality of life, no differences were found between groups. CONCLUSIONS: Diabetes was not associated with increased mortality or reduced quality of life in a general population of medical ICU patients. However, once comorbidities associated with diabetes occurred, the survival rate of patients with comorbidities associated with hyperglycemia was significantly reduced.
PURPOSE:Diabetes mellitus represents an increasing problem for patients and health care systems worldwide. We sought to investigate the effect of diabetes and its associated comorbidities on long-term survival and quality of life following an admission to a medical intensive care unit (ICU). METHODS: A total of 6662 consecutive patients admitted to ICU between 2004 and 2009 were included (patients with diabetes n=796, non-diabeticpatients n=5866). The primary endpoint of the study was death of any cause. Data on mortality was collected upon review of medical records or phone interviews. Moreover, a questionnaire was sent to 500 randomly selected patients addressing Health related Quality of Life (HrQoL) after ICU treatment. RESULTS: Overall mortality did not differ significantly between diabetic and non-diabeticpatients after ICU treatment (mean follow-up time: 490 days). For a subgroup of patients already exhibiting comorbidities associated with diabetes, the mortality rate was significantly higher (p=0.022). Regarding quality of life, no differences were found between groups. CONCLUSIONS:Diabetes was not associated with increased mortality or reduced quality of life in a general population of medical ICU patients. However, once comorbidities associated with diabetes occurred, the survival rate of patients with comorbidities associated with hyperglycemia was significantly reduced.
Authors: Bernhard Wernly; Peter Jirak; Michael Lichtenauer; Marcus Franz; Bjoern Kabisch; Paul C Schulze; Kristina Braun; Johanna Muessig; Maryna Masyuk; Bernhard Paulweber; Alexander Lauten; Uta C Hoppe; Malte Kelm; Christian Jung Journal: Med Princ Pract Date: 2018-12-13 Impact factor: 1.927
Authors: Bernhard Wernly; Michael Lichtenauer; Marcus Franz; Bjoern Kabisch; Johanna Muessig; Maryna Masyuk; Uta C Hoppe; Malte Kelm; Christian Jung Journal: PLoS One Date: 2017-02-02 Impact factor: 3.240
Authors: David W Freeman; Nicole Noren Hooten; Erez Eitan; Jamal Green; Nicolle A Mode; Monica Bodogai; Yongqing Zhang; Elin Lehrmann; Alan B Zonderman; Arya Biragyn; Josephine Egan; Kevin G Becker; Mark P Mattson; Ngozi Ejiogu; Michele K Evans Journal: Diabetes Date: 2018-05-02 Impact factor: 9.337
Authors: Bernhard Wernly; Michael Lichtenauer; Marcus Franz; Bjoern Kabisch; Johanna Muessig; Maryna Masyuk; Malte Kelm; Uta C Hoppe; Christian Jung Journal: Int J Mol Sci Date: 2016-09-21 Impact factor: 5.923
Authors: Jessie N Zurita-Cruz; Leticia Manuel-Apolinar; María Luisa Arellano-Flores; Alejandro Gutierrez-Gonzalez; Alma Gloria Najera-Ahumada; Nelly Cisneros-González Journal: Health Qual Life Outcomes Date: 2018-05-15 Impact factor: 3.186