BACKGROUND: The aim of this systematic review was to evaluate the relationship between obesity and peroxisome proliferator-activated receptor-gamma (PPARx03B3;) Pro12Ala polymorphism in healthy adults. SUMMARY: Weighted mean differences (WMDs) of body mass index (BMI) were calculated for different inheritance models and subgroups. Fifty-six studies were eligible for inclusion in the meta-analysis. The result shows that the Ala allele of this polymorphism was associated with increased WMD in mean BMI (WMD = 0.29, 95% CI 0.10-0.48, p = 0.003). The Ala carriers were associated with increased WMD in mean BMI values in both genders and in the Caucasian subgroup. The associations were seen among people with higher levels of BMI (BMI ≥35). MESSAGE: The Ala allele of the PPARx03B3; Pro12Ala polymorphism in healthy adults was associated with increased BMI under a dominant model of inheritance.
BACKGROUND: The aim of this systematic review was to evaluate the relationship between obesity and peroxisome proliferator-activated receptor-gamma (PPARx03B3;) Pro12Ala polymorphism in healthy adults. SUMMARY: Weighted mean differences (WMDs) of body mass index (BMI) were calculated for different inheritance models and subgroups. Fifty-six studies were eligible for inclusion in the meta-analysis. The result shows that the Ala allele of this polymorphism was associated with increased WMD in mean BMI (WMD = 0.29, 95% CI 0.10-0.48, p = 0.003). The Ala carriers were associated with increased WMD in mean BMI values in both genders and in the Caucasian subgroup. The associations were seen among people with higher levels of BMI (BMI ≥35). MESSAGE: The Ala allele of the PPARx03B3; Pro12Ala polymorphism in healthy adults was associated with increased BMI under a dominant model of inheritance.
Authors: Yunhua L Muller; Michael Saporito; Samantha Day; Khushdeep Bandesh; Cigdem Koroglu; Sayuko Kobes; William C Knowler; Robert L Hanson; Cristopher V Van Hout; Alan R Shuldiner; Clifton Bogardus; Leslie J Baier Journal: Eur J Hum Genet Date: 2022-06-10 Impact factor: 5.351
Authors: Farida V Valeeva; Mariya S Medvedeva; Kamilya B Khasanova; Elena V Valeeva; Tatyana A Kiseleva; Emiliya S Egorova; Craig Pickering; Ildus I Ahmetov Journal: Mol Biol Rep Date: 2022-03-15 Impact factor: 2.742
Authors: Jaroslav A Hubacek; Hynek Pikhart; Ruzena Kubinova; Anne Peasey; Sofia Malyutina; Andrzej Pajak; Abdonas Tamosiunas; Martin Bobak Journal: Ann Nutr Metab Date: 2016-05-31 Impact factor: 3.374
Authors: Prasad G Kamble; Stefan Gustafsson; Maria J Pereira; Per Lundkvist; Naomi Cook; Lars Lind; Paul W Franks; Tove Fall; Jan W Eriksson; Erik Ingelsson Journal: Ups J Med Sci Date: 2018-01-05 Impact factor: 2.384