Zhilong Xiao1, Zhimin Pei2, Min Yuan1, Xueli Li1, Shenjian Chen1, Lijun Xu3. 1. Department of Neurology, The Second Affiliated Hospital of Nanchang University, Jiangxi Province, China. 2. Schistosomiasis Epidemic Prevention Station of Nanchang County, Nanchang City, Jiangxi Province, China. 3. Department of Neurology, The Second Affiliated Hospital of Nanchang University, Jiangxi Province, China. Electronic address: xulijun20050901@sina.com.
Abstract
OBJECTIVE: Observational studies, to date, have provided inconsistent findings on whether inflammatory bowel disease (IBD) is associated with an increased risk of stroke. We therefore performed a meta-analysis to evaluate the association of IBD and its specific subtypes with risk of stroke. DESIGN: We searched electronic databases for studies through May 13, 2015 assessing risk of stroke in patients with IBD. Cohort and case-control studies that reported incident cases of stroke in patients with IBD and a non-IBD control population were eligible. We calculated pooled hazard ratios (HRs) with 95% confidence intervals (CIs). RESULTS: A total of 8 articles (126,493 IBD patients and 4748 cases of stroke) were included in this meta-analysis. The presence of IBD revealed a trend toward a modest increase in the risk of stroke incidence (HR = 1.29; 95% CI, 1.16-1.43). After subgroup analysis, Crohn's disease showed an increased risk of stroke incidence (7 studies: HR = 1.32; 95% CI, 1.13-1.56), and a significant association was also identified in ulcerative colitis (6 studies: HR = 1.18; 95% CI, 1.06-1.31). In addition, this risk is higher in women (6 studies: HR = 1.49; 95% CI, 1.24-1.79) than in men (HR = 1.22; 95% CI, 1.12-1.32). In the overall analysis we found considerable heterogeneity. CONCLUSION: Our results show a positive association between IBD and the risk of stroke.
OBJECTIVE: Observational studies, to date, have provided inconsistent findings on whether inflammatory bowel disease (IBD) is associated with an increased risk of stroke. We therefore performed a meta-analysis to evaluate the association of IBD and its specific subtypes with risk of stroke. DESIGN: We searched electronic databases for studies through May 13, 2015 assessing risk of stroke in patients with IBD. Cohort and case-control studies that reported incident cases of stroke in patients with IBD and a non-IBD control population were eligible. We calculated pooled hazard ratios (HRs) with 95% confidence intervals (CIs). RESULTS: A total of 8 articles (126,493 IBD patients and 4748 cases of stroke) were included in this meta-analysis. The presence of IBD revealed a trend toward a modest increase in the risk of stroke incidence (HR = 1.29; 95% CI, 1.16-1.43). After subgroup analysis, Crohn's disease showed an increased risk of stroke incidence (7 studies: HR = 1.32; 95% CI, 1.13-1.56), and a significant association was also identified in ulcerative colitis (6 studies: HR = 1.18; 95% CI, 1.06-1.31). In addition, this risk is higher in women (6 studies: HR = 1.49; 95% CI, 1.24-1.79) than in men (HR = 1.22; 95% CI, 1.12-1.32). In the overall analysis we found considerable heterogeneity. CONCLUSION: Our results show a positive association between IBD and the risk of stroke.
Authors: Charles N Bernstein; Eric I Benchimol; Alain Bitton; Sanjay K Murthy; Geoffrey C Nguyen; Kate Lee; Jane Cooke-Lauder; Gilaad G Kaplan Journal: J Can Assoc Gastroenterol Date: 2018-11-02