| Literature DB >> 26360644 |
Eric A F Herbst1,1, Arend Bonen1,1, Graham P Holloway1,1.
Abstract
Changes in nuclear receptor interacting protein 140 (RIP140) influences mitochondrial content in skeletal muscle; however, the translation of these findings to the brain has not been investigated. The present study examined the impact of overexpressing and ablating RIP140 on mitochondrial content in muscle and the cortex through examining mRNA, mtDNA, and mitochondrial protein content. Our results show that changes in RIP140 expression significantly alters markers of mitochondrial content in skeletal muscle but not the brain.Entities:
Keywords: PGC-1α; biogenèse mitochondriale; brain; cerveau; contenu mitochondrial; contrôle transcriptionnel; mitochondrial biogenesis; mitochondrial content; transcriptional control
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Year: 2015 PMID： 26360644 DOI： 10.1139/apnm-2015-0192
Source DB: PubMed Journal: Appl Physiol Nutr Metab ISSN： 1715-5312 Impact factor: 2.665