Valentina Arnao1, Antonio Cinturino1, Francesca Valentino1, Valentina Perini1, Sergio Mastrilli1, Gabriele Bellavia1, Giovanni Savettieri1, Sabrina Realmuto1, Marco D'Amelio2. 1. Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (Department of Experimental Biomedicine and Clinical Neurosciences), Università degli Studi di Palermo, via del Vespro, 129, Palermo, Italy. 2. Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (Department of Experimental Biomedicine and Clinical Neurosciences), Università degli Studi di Palermo, via del Vespro, 129, Palermo, Italy. marco.damelio@unipa.it.
Abstract
BACKGROUND: Autonomic symptoms and sleep disorders are common non-motor symptoms of Parkinson disease (PD), which are correlated with poor quality of life for patients. PURPOSE: To assess the frequency of autonomic symptoms in a consecutive series of PD patients and to correlate them with other motor and non-motor symptoms. METHODS: All consecutive non-demented PD patients who underwent an extensive evaluation including Hoehn and Yahr staging, Unified Parkinson's Disease Rating Scale, Beck's Depression Inventory, Neuropsychiatric Inventory, PDQ-39 Scale, the Parkinson's diseases Sleep Scale, the Epworth Sleepiness Scale and SCOPA-AUT scale were enrolled. Comorbidity has been also considered. Supine to standing position blood pressure and cardiac frequency changes were also measured. RESULTS: 135 PD patients were included (mean age at interview 67.7; mean disease duration: 5.3 years). Patients were stratified according to mean SCOPA-AUT scale score (13.1). Those with higher SCOPA-AUT scale score were significantly older, had longer disease duration, worse disease stage, worse quality of sleep, were more severely affected, and were also taking a higher dosage of levodopa. At multivariate analysis, older age, longer disease duration, and worse quality of sleep were independently associated with higher SCOPA-AUT scale scores. CONCLUSIONS: Our results remark the role of autonomic symptoms in PD. In our patient population, characterized by mild to moderate disease severity, most of the patients complained of autonomic nervous system involvement (84%). A significant association between autonomic symptoms and sleep disorders was also observed.
BACKGROUND: Autonomic symptoms and sleep disorders are common non-motor symptoms of Parkinson disease (PD), which are correlated with poor quality of life for patients. PURPOSE: To assess the frequency of autonomic symptoms in a consecutive series of PDpatients and to correlate them with other motor and non-motor symptoms. METHODS: All consecutive non-demented PDpatients who underwent an extensive evaluation including Hoehn and Yahr staging, Unified Parkinson's Disease Rating Scale, Beck's Depression Inventory, Neuropsychiatric Inventory, PDQ-39 Scale, the Parkinson's diseasesSleep Scale, the Epworth Sleepiness Scale and SCOPA-AUT scale were enrolled. Comorbidity has been also considered. Supine to standing position blood pressure and cardiac frequency changes were also measured. RESULTS: 135 PDpatients were included (mean age at interview 67.7; mean disease duration: 5.3 years). Patients were stratified according to mean SCOPA-AUT scale score (13.1). Those with higher SCOPA-AUT scale score were significantly older, had longer disease duration, worse disease stage, worse quality of sleep, were more severely affected, and were also taking a higher dosage of levodopa. At multivariate analysis, older age, longer disease duration, and worse quality of sleep were independently associated with higher SCOPA-AUT scale scores. CONCLUSIONS: Our results remark the role of autonomic symptoms in PD. In our patient population, characterized by mild to moderate disease severity, most of the patients complained of autonomic nervous system involvement (84%). A significant association between autonomic symptoms and sleep disorders was also observed.
Authors: Marco D'Amelio; Valeria Terruso; Barbara Palmeri; Norma Di Benedetto; Giorgia Famoso; Paolo Cottone; Paolo Aridon; Paolo Ragonese; Giovanni Savettieri Journal: Neurol Sci Date: 2009-02-03 Impact factor: 3.307
Authors: Christopher H Gibbons; David K Simon; Meilin Huang; Barbara Tilley; Michael J Aminoff; Jacquelyn L Bainbridge; Matthew Brodsky; Roy Freeman; John Goudreau; Robert W Hamill; Sheng T Luo; Carlos Singer; Aleksandar Videnovic; Ivan Bodis-Wollner; Pei S Wong Journal: Auton Neurosci Date: 2017-04-14 Impact factor: 3.145
Authors: V Arnao; A Cinturino; S Mastrilli; C Buttà; C Maida; A Tuttolomondo; P Aridon; M D'Amelio Journal: BMC Neurol Date: 2020-04-23 Impact factor: 2.474
Authors: Naveed Malek; Michael A Lawton; Katherine A Grosset; Nin Bajaj; Roger A Barker; David J Burn; Tom Foltynie; John Hardy; Huw R Morris; Nigel M Williams; Yoav Ben-Shlomo; Nicholas W Wood; Donald G Grosset Journal: Mov Disord Clin Pract Date: 2016-11-24
Authors: Young Hee Sung; Hee Jin Kim; Seong Beom Koh; Joong Seok Kim; Sang Jin Kim; Sang Myung Cheon; Jin Whan Cho; Yoon Joong Kim; Hyeo Il Ma; Mee Young Park; Jong Sam Baik; Phil Hyu Lee; Sun Ju Chung; Jong Min Kim; In Uk Song; Han Joon Kim; Ji Young Kim; Do Young Kwon; Jae Hyeok Lee; Jee Young Lee; Ji Seon Kim; Ji Young Yun; Jin Yong Hong; Mi Jung Kim; Jinyoung Youn; Ji Sun Kim; Eung Seok Oh; Hui Jun Yang; Won Tae Yoon; Sooyeoun You; Kyum Yil Kwon; Hyung Eun Park; Su Yun Lee; Younsoo Kim; Hee Tae Kim; Tae Beom Ahn Journal: J Korean Med Sci Date: 2018-01-08 Impact factor: 2.153