Richard D Semba1, Luigi Ferrucci2, Kai Sun3, Eleanor Simonsick2, Randi Turner3, Iva Miljkovic4, Tamara Harris5, Ann V Schwartz6, Keiko Asao7, Stephen Kritchevsky8, Anne B Newman4. 1. Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. rdsemba@jhmi.edu. 2. National Institute on Aging, NIH, Baltimore, Maryland. 3. Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. 4. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania. 5. Intramural Research Program, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland. 6. Department of Epidemiology and Biostatistics, University of California San Francisco School of Medicine. 7. Department of Preventive Medicine, University of Tennessee, Memphis. 8. Sticht Center on Aging, Wake Forest University, Winston-Salem, North Carolina.
Abstract
BACKGROUND: Although the "anti-aging hormone" klotho is associated with sarcopenia in mice, the relationship between klotho and muscle strength in older adults is not well known. METHODS: Plasma klotho concentrations were measured in 2,734 older adults, aged 71-80 years, who participated in the Health, Aging and Body Composition Study, a prospective observational cohort study conducted in Memphis, TN and Pittsburgh, PA. Knee extension strength was measured using isokinetic dynamometry at baseline and follow-up 2 and 4 years later. Knee extension strength was normalized for weight. RESULTS: At baseline, participants in the highest tertile of plasma klotho had higher knee extension strength (β = .72, standard error [SE] = .018, p < .0001) compared with those in the lowest tertile in a multivariable linear regression model adjusting for age, sex, race, smoking, study site, C-reactive protein, interleukin-6, and diabetes. Participants in the highest tertile of plasma klotho at baseline had less of a decline in knee strength over 4 years of follow-up (β = -.025, SE = .011, p = .02) compared with those in the lowest tertile in a multivariable linear regression model adjusting for the same covariates above. CONCLUSIONS: Plasma klotho concentrations were an independent predictor of changes in knee strength over time in older adults. Further studies are needed to identify the biological mechanisms by which circulating klotho could modify skeletal muscle strength.
BACKGROUND: Although the "anti-aging hormone" klotho is associated with sarcopenia in mice, the relationship between klotho and muscle strength in older adults is not well known. METHODS: Plasma klotho concentrations were measured in 2,734 older adults, aged 71-80 years, who participated in the Health, Aging and Body Composition Study, a prospective observational cohort study conducted in Memphis, TN and Pittsburgh, PA. Knee extension strength was measured using isokinetic dynamometry at baseline and follow-up 2 and 4 years later. Knee extension strength was normalized for weight. RESULTS: At baseline, participants in the highest tertile of plasma klotho had higher knee extension strength (β = .72, standard error [SE] = .018, p < .0001) compared with those in the lowest tertile in a multivariable linear regression model adjusting for age, sex, race, smoking, study site, C-reactive protein, interleukin-6, and diabetes. Participants in the highest tertile of plasma klotho at baseline had less of a decline in knee strength over 4 years of follow-up (β = -.025, SE = .011, p = .02) compared with those in the lowest tertile in a multivariable linear regression model adjusting for the same covariates above. CONCLUSIONS: Plasma klotho concentrations were an independent predictor of changes in knee strength over time in older adults. Further studies are needed to identify the biological mechanisms by which circulating klotho could modify skeletal muscle strength.
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