Literature DB >> 26359111

Viral bioterrorism: Learning the lesson of Ebola virus in West Africa 2013-2015.

Orlando Cenciarelli1, Valentina Gabbarini2, Stefano Pietropaoli3, Andrea Malizia4, Annalaura Tamburrini2, Gian Marco Ludovici2, Mariachiara Carestia4, Daniele Di Giovanni4, Alessandro Sassolini5, Leonardo Palombi6, Carlo Bellecci4, Pasquale Gaudio4.   

Abstract

Among the potential biological agents suitable as a weapon, Ebola virus represents a major concern. Classified by the CDC as a category A biological agent, Ebola virus causes severe hemorrhagic fever, characterized by high case-fatality rate; to date, no vaccine or approved therapy is available. The EVD epidemic, which broke out in West Africa since the late 2013, has got the issue of the possible use of Ebola virus as biological warfare agent (BWA) to come to the fore once again. In fact, due to its high case-fatality rate, population currently associates this pathogen to a real and tangible threat. Therefore, its use as biological agent by terrorist groups with offensive purpose could have serious repercussions from a psychosocial point of view as well as on closely sanitary level. In this paper, after an initial study of the main characteristics of Ebola virus, its potential as a BWA was evaluated. Furthermore, given the spread of the epidemic in West Africa in 2014 and 2015, the potential dissemination of the virus from an urban setting was evaluated. Finally, it was considered the actual possibility to use this agent as BWA in different scenarios, and the potential effects on one or more nation's stability.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  BWA; Bioterrorism; Ebola virus; Hemorrhagic fever; West Africa

Mesh:

Substances:

Year:  2015        PMID: 26359111     DOI: 10.1016/j.virusres.2015.09.002

Source DB:  PubMed          Journal:  Virus Res        ISSN: 0168-1702            Impact factor:   3.303


  6 in total

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Authors:  Joseph P Wood; William Richter; Michelle Sunderman; M Worth Calfee; Shannon Serre; Leroy Mickelsen
Journal:  Environ Sci Technol       Date:  2020-03-03       Impact factor: 9.028

2.  One-step single-tube accelerated quantitative nucleoprotein gene-specific reverse transcription loop-mediated isothermal gene amplification (RT-LAMP) assay for rapid, real-time & reliable clinical detection of Ebola virus.

Authors:  Jyoti S Kumar; Paban Kumar Dash; Ambuj Srivastava; Shashi Sharma; Kundan Tandel; Manmohan Parida
Journal:  Indian J Med Res       Date:  2021-04       Impact factor: 5.274

Review 3.  Auxotrophy to Xeno-DNA: an exploration of combinatorial mechanisms for a high-fidelity biosafety system for synthetic biology applications.

Authors:  Christopher M Whitford; Saskia Dymek; Denise Kerkhoff; Camilla März; Olga Schmidt; Maximilian Edich; Julian Droste; Boas Pucker; Christian Rückert; Jörn Kalinowski
Journal:  J Biol Eng       Date:  2018-08-14       Impact factor: 4.355

4.  Biosafety and biosecurity.

Authors:  Dongsheng Zhou; Hongbin Song; Jianwei Wang; Zhenjun Li; Shuai Xu; Xingzhao Ji; Xuexin Hou; Jianguo Xu
Journal:  J Biosaf Biosecur       Date:  2019-02-20

5.  Nurses' and Medical Officers' Knowledge, Attitude, and Preparedness Toward Potential Bioterrorism Attacks.

Authors:  Confidence A Atakro; Stella B Addo; Janet S Aboagye; Alice A Blay; Kwaku G Amoa-Gyarteng; Awube Menlah; Isabella Garti; Dorcas F Agyare; Kumah K Junior; Limmy Sarpong
Journal:  SAGE Open Nurs       Date:  2019-05-03

6.  Post-exposure treatment of Ebola virus disease in guinea pigs using EBOTAb, an ovine antibody-based therapeutic.

Authors:  Stuart D Dowall; Andrew Bosworth; Emma Rayner; Irene Taylor; John Landon; Ian Cameron; Ruth Coxon; Ibrahim Al Abdulla; Victoria A Graham; Graham Hall; Gary Kobinger; Roger Hewson; Miles W Carroll
Journal:  Sci Rep       Date:  2016-07-28       Impact factor: 4.379

  6 in total

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