Literature DB >> 26358186

Cutting in on a secretase pas de deux.

Michael S Wolfe1.   

Abstract

Two proteolytic enzymes, β- and γ-secretases, work together to produce the amyloid β-peptide of Alzheimer's disease. New evidence suggests that these proteases directly interact and compounds that disrupt this interaction reduce amyloid β-peptide levels without directly blocking either enzyme's solo activity.

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Year:  2015        PMID： 26358186      PMCID： PMC4650623          DOI： 10.1038/cr.2015.106

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  10 in total

Review 1.  γ-Secretase inhibitors and modulators for Alzheimer's disease.

Authors:  Michael S Wolfe
Journal:  J Neurochem       Date:  2011-11-28       Impact factor: 5.372

2.  Lessons from a failed γ-secretase Alzheimer trial.

Authors:  Bart De Strooper
Journal:  Cell       Date:  2014-11-06       Impact factor: 41.582

3.  Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

Authors:  Naoto Watanabe; Image Image Image Image; Shizuka Takagi; Image Image Image Image; Aya Tominaga; Image Image Image; Taisuke Tomita; Image Image Image Image; Takeshi Iwatsubo; Image Image Image
Journal:  J Biol Chem       Date:  2010-04-23       Impact factor: 5.157

4.  Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

Authors:  Akira Kuzuya; Kengo Uemura; Naoyuki Kitagawa; Nobuhisa Aoyagi; Takeshi Kihara; Haruaki Ninomiya; Shoichi Ishiura; Ryosuke Takahashi; Shun Shimohama
Journal:  J Neurosci Res       Date:  2007-01       Impact factor: 4.164

Review 5.  beta-Secretase as a therapeutic target for Alzheimer's disease.

Authors:  Arun K Ghosh; Sandra Gemma; Jordan Tang
Journal:  Neurotherapeutics       Date:  2008-07       Impact factor: 7.620

6.  BACE1 interacts with nicastrin.

Authors:  Chinatsu Hattori; Masashi Asai; Yoko Oma; Yoshihiro Kino; Noboru Sasagawa; Takaomi C Saido; Kei Maruyama; Shoichi Ishiura
Journal:  Biochem Biophys Res Commun       Date:  2002-05-17       Impact factor: 3.575

7.  Presenilin-1 interacts directly with the beta-site amyloid protein precursor cleaving enzyme (BACE1).

Authors:  Sébastien S Hébert; Valérie Bourdages; Chantal Godin; Mélissa Ferland; Madeleine Carreau; Georges Lévesque
Journal:  Neurobiol Dis       Date:  2003-08       Impact factor: 5.996

Review 8.  A century of Alzheimer's disease.

Authors:  Michel Goedert; Maria Grazia Spillantini
Journal:  Science       Date:  2006-11-03       Impact factor: 47.728

9.  Structural basis of human γ-secretase assembly.

Authors:  Linfeng Sun; Lingyun Zhao; Guanghui Yang; Chuangye Yan; Rui Zhou; Xiaoyuan Zhou; Tian Xie; Yanyu Zhao; Shenjie Wu; Xueming Li; Yigong Shi
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-27       Impact factor: 11.205

10.  Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis.

Authors:  Jin Cui; Xiaoyin Wang; Xiaohang Li; Xin Wang; Chenlu Zhang; Wei Li; Yangming Zhang; Haifeng Gu; Xin Xie; Fajun Nan; Jian Zhao; Gang Pei
Journal:  Cell Discov       Date:  2015-08-18       Impact factor: 10.849
  10 in total

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