Yoshikatsu Noda1, Kenji Sekiguchi1, Nobuo Kohara2, Fumio Kanda1, Tatsushi Toda1. 1. Division of Neurology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chou-ku, Kobe City, Hyogo, 650-0017, Japan. 2. Division of Neurology, Kobe City Medical Center General Hospital, Kobe City, Hyogo, Japan.
Abstract
INTRODUCTION: Noninvasive evaluation of respiratory function in patients with various neuromuscular disorders is important for predicting life expectancy. METHODS: We performed B-mode ultrasonography (USG) and nerve conduction studies in 37 patients (16 had amyotrophic lateral sclerosis; 11, myopathy; and 10, neuropathy) and 10 controls. USG of the diaphragm was performed in the supine position using a linear probe over the intercostal space at the anterior axillary line. Diaphragm muscle thickness was measured at end-expiration. The amplitude of diaphragm compound muscle action potentials (CMAP) was obtained by phrenic nerve stimulation with a surface electrode. Respiratory function was measured with standard pulmonary function tests including forced vital capacity (FVC). RESULTS: Diaphragm thickness was significantly correlated with FVC (r = 0.74) and CMAP amplitude (r = 0.53). CONCLUSIONS: Diaphragm USG is useful for objective evaluation of pulmonary function in neuromuscular disorders without requiring undue patient effort or cooperation.
INTRODUCTION: Noninvasive evaluation of respiratory function in patients with various neuromuscular disorders is important for predicting life expectancy. METHODS: We performed B-mode ultrasonography (USG) and nerve conduction studies in 37 patients (16 had amyotrophic lateral sclerosis; 11, myopathy; and 10, neuropathy) and 10 controls. USG of the diaphragm was performed in the supine position using a linear probe over the intercostal space at the anterior axillary line. Diaphragm muscle thickness was measured at end-expiration. The amplitude of diaphragm compound muscle action potentials (CMAP) was obtained by phrenic nerve stimulation with a surface electrode. Respiratory function was measured with standard pulmonary function tests including forced vital capacity (FVC). RESULTS: Diaphragm thickness was significantly correlated with FVC (r = 0.74) and CMAP amplitude (r = 0.53). CONCLUSIONS: Diaphragm USG is useful for objective evaluation of pulmonary function in neuromuscular disorders without requiring undue patient effort or cooperation.
Authors: Laura López-Viñas; Juan Vega-Villar; Esmeralda Rocío-Martín; Patricia García-García; Elena De La Rosa Santiago; Jose María Galván-Román; Rybel Wix-Ramos Journal: Eur J Transl Myol Date: 2022-06-21
Authors: James Rooney; Deirdre Murray; Anna Campion; Hannah Moloney; Rachel Tattersall; Mark Doherty; Michaela Hammond; Mark Heverin; Russell McLaughlin; Orla Hardiman Journal: HRB Open Res Date: 2019-09-26