Genome-Wide Protein Function Prediction through Multi-Instance Multi-Label Learning.

Automated annotation of protein function is challenging. As the number of sequenced genomes rapidly grows, the vast majority of proteins can only be annotated computationally. Nature often brings several domains together to form multi-domain and multi-functional proteins with a vast number of possibilities, and each domain may fulfill its own function independently or in a concerted manner with its neighbors. Thus, it is evident that the protein function prediction problem is naturally and inherently Multi-Instance Multi-Label (MIML) learning tasks. Based on the state-of-the-art MIML algorithm MIMLNN, we propose a novel ensemble MIML learning framework EnMIMLNN and design three algorithms for this task by combining the advantage of three kinds of Hausdorff distance metrics. Experiments on seven real-world organisms covering the biological three-domain system, i.e., archaea, bacteria, and eukaryote, show that the EnMIMLNN algorithms are superior to most state-of-the-art MIML and Multi-Label learning algorithms.