Literature DB >> 26356172

Controlling release, unfolding and dissociation of membrane protein complexes in the gas phase through collisional cooling.

Michael Landreh1, Idlir Liko, Povilas Uzdavinys, Mathieu Coincon, Jonathan T S Hopper, David Drew, Carol V Robinson.   

Abstract

Mass spectrometry of intact membrane protein complexes requires removal of the detergent micelle by collisional activation. We demonstrate that the necessary energy can be obtained by adjusting the degree of collisional cooling in the ion source. This enables us to extend the energy regime for dissociation of membrane protein complexes.

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Year:  2015        PMID： 26356172      PMCID： PMC4735947          DOI： 10.1039/c5cc07045g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  14 in total

1.  A tandem mass spectrometer for improved transmission and analysis of large macromolecular assemblies.

Authors:  Frank Sobott; Helena Hernández; Margaret G McCammon; Mark A Tito; Carol V Robinson
Journal:  Anal Chem       Date:  2002-03-15       Impact factor: 6.986

2.  The effect of the source pressure on the abundance of ions of noncovalent protein assemblies in an electrospray ionization orthogonal time-of-flight instrument.

Authors:  N Tahallah; M Pinkse; C S Maier; A J Heck
Journal:  Rapid Commun Mass Spectrom       Date:  2001       Impact factor: 2.419

3.  Improving the performance of a quadrupole time-of-flight instrument for macromolecular mass spectrometry.

Authors:  Robert H H van den Heuvel; Esther van Duijn; Hortense Mazon; Silvia A Synowsky; Kristina Lorenzen; Cees Versluis; Stan J J Brouns; Dave Langridge; John van der Oost; John Hoyes; Albert J R Heck
Journal:  Anal Chem       Date:  2006-11-01       Impact factor: 6.986

4.  Collision induced unfolding of protein ions in the gas phase studied by ion mobility-mass spectrometry: the effect of ligand binding on conformational stability.

Authors:  Jonathan T S Hopper; Neil J Oldham
Journal:  J Am Soc Mass Spectrom       Date:  2009-07-01       Impact factor: 3.109

5.  The role of the detergent micelle in preserving the structure of membrane proteins in the gas phase.

Authors:  Eamonn Reading; Idlir Liko; Timothy M Allison; Justin L P Benesch; Arthur Laganowsky; Carol V Robinson
Journal:  Angew Chem Int Ed Engl       Date:  2015-02-18       Impact factor: 15.336

6.  Detergent release prolongs the lifetime of native-like membrane protein conformations in the gas-phase.

Authors:  Antoni J Borysik; Dominic J Hewitt; Carol V Robinson
Journal:  J Am Chem Soc       Date:  2013-04-10       Impact factor: 15.419

7.  Micelles protect membrane complexes from solution to vacuum.

Authors:  Nelson P Barrera; Natalie Di Bartolo; Paula J Booth; Carol V Robinson
Journal:  Science       Date:  2008-06-12       Impact factor: 47.728

8.  Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry.

Authors:  Albert Konijnenberg; Duygu Yilmaz; Helgi I Ingólfsson; Anna Dimitrova; Siewert J Marrink; Zhuolun Li; Catherine Vénien-Bryan; Frank Sobott; Armağan Koçer
Journal:  Proc Natl Acad Sci U S A       Date:  2014-11-17       Impact factor: 11.205

9.  Detergent-free mass spectrometry of membrane protein complexes.

Authors:  Jonathan T S Hopper; Yvonne Ting-Chun Yu; Dianfan Li; Alison Raymond; Mark Bostock; Idlir Liko; Victor Mikhailov; Arthur Laganowsky; Justin L P Benesch; Martin Caffrey; Daniel Nietlispach; Carol V Robinson
Journal:  Nat Methods       Date:  2013-10-13       Impact factor: 28.547

10.  Membrane proteins bind lipids selectively to modulate their structure and function.

Authors:  Arthur Laganowsky; Eamonn Reading; Timothy M Allison; Martin B Ulmschneider; Matteo T Degiacomi; Andrew J Baldwin; Carol V Robinson
Journal:  Nature       Date:  2014-06-05       Impact factor: 49.962
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  6 in total

1.  Native MS Analysis of Bacteriorhodopsin and an Empty Nanodisc by Orthogonal Acceleration Time-of-Flight, Orbitrap and Ion Cyclotron Resonance.

Authors:  Iain D G Campuzano; Huilin Li; Dhanashri Bagal; Jennifer L Lippens; Juraj Svitel; Robert J M Kurzeja; Han Xu; Paul D Schnier; Joseph A Loo
Journal:  Anal Chem       Date:  2016-12-01       Impact factor: 6.986

2.  Characterization of Membrane Protein-Lipid Interactions by Mass Spectrometry Ion Mobility Mass Spectrometry.

Authors:  Yang Liu; Xiao Cong; Wen Liu; Arthur Laganowsky
Journal:  J Am Soc Mass Spectrom       Date:  2016-12-06       Impact factor: 3.109

3.  Native mass spectrometry and ion mobility characterize the orange carotenoid protein functional domains.

Authors:  Hao Zhang; Haijun Liu; Yue Lu; Nathan R Wolf; Michael L Gross; Robert E Blankenship
Journal:  Biochim Biophys Acta       Date:  2016-02-24

Review 4.  Approaches to Heterogeneity in Native Mass Spectrometry.

Authors:  Amber D Rolland; James S Prell
Journal:  Chem Rev       Date:  2021-09-01       Impact factor: 72.087

5.  Electrospray ionization of native membrane proteins proceeds via a charge equilibration step.

Authors:  Hsin-Yung Yen; Mia L Abramsson; Mark T Agasid; Dilraj Lama; Joseph Gault; Idlir Liko; Margit Kaldmäe; Mihkel Saluri; Abdul Aziz Qureshi; Albert Suades; David Drew; Matteo T Degiacomi; Erik G Marklund; Timothy M Allison; Carol V Robinson; Michael Landreh
Journal:  RSC Adv       Date:  2022-04-01       Impact factor: 3.361

6.  Increasing Collisional Activation of Protein Complexes Using Smaller Aperture Source Sampling Cones on a Synapt Q-IM-TOF Instrument with a Stepwave Source.

Authors:  Jesse W Wilson; Micah T Donor; Samantha O Shepherd; James S Prell
Journal:  J Am Soc Mass Spectrom       Date:  2020-07-15       Impact factor: 3.109
  6 in total

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