| Literature DB >> 26354795 |
Bas B Oude Munnink1, Matthew Cotten2, Martin Deijs1, Maarten F Jebbink1, Margreet Bakker1, Seyed Mohammad Jazaeri Farsani1, Marta Canuti1, Paul Kellam2, Lia van der Hoek1.
Abstract
Recently, four new viruses belonging to an unassigned family within the order Picornavirales were identified in excrements of healthy carp (fisavirus) and pigs (posavirus 1, 2 and 3). We report the detection and characterization of a fifth virus present in human faeces. The virus, named human stool-associated RNA virus (husavirus), contains a single ORF encoding a putative 2993 AA polyprotein, with a Hel-Pro-Pol replication block, typical for the Picornavirales. Phylogenetic analysis revealed that the closest relative to husavirus is posavirus 1, and together they cluster with fisavirus, posavirus 2 and 3 and a roundworm (Ascaris suum) derived virus. Husavirus was detected in eight human stool samples collected in 1984 (n52), 1985 (n54), 1995 (n51) and 2014 (n51). From three strains of husavirus from 1984 and 1985 the full genome sequence was determined, showing less than 5% intraspecies variation in the nucleotide composition. The host of this virus remains to be determined.Entities:
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Year: 2015 PMID： 26354795 DOI： 10.1099/jgv.0.000279
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891