Gyung-Mee Kim1, Jong-Min Woo2, Sun-Young Jung3, Sangjin Shin4, Hyun Jin Song5, Jooyeon Park4, Jeonghoon Ahn4. 1. National Evidence-based Healthcare Collaborating Agency (NECA), Seoul, Korea Department of Psychiatry, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea. 2. National Evidence-based Healthcare Collaborating Agency (NECA), Seoul, Korea Department of Psychiatry, Seoul Paik Hospital, Inje University School of Medicine, Seoul, Korea Stress Research Institute, Inje University, Seoul, Korea jongmin.woo@gmail.com. 3. National Evidence-based Healthcare Collaborating Agency (NECA), Seoul, Korea Korea Institute of Drug Safety and Risk Management (KIDS), Seoul, Korea. 4. National Evidence-based Healthcare Collaborating Agency (NECA), Seoul, Korea. 5. National Evidence-based Healthcare Collaborating Agency (NECA), Seoul, Korea School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Abstract
OBJECTIVES: Depression and diabetes are closely biologically and behaviorally intertwined. We examined the impact of comorbid diabetes mellitus on the incidence of serious psychiatric outcomes among patients with depression. METHODS: We used claims data from the Korean Health Insurance Review & Assessment Service database of patients who were diagnosed with depression within one year of an index prescription for antidepressants between January 2007 and June 2008. We investigated the association between the comorbidity of diabetes mellitus and serious psychiatric outcomes of depression, such as psychiatric hospitalization, psychiatric emergency room visits, and suicide attempts. RESULTS: Among 200,936 patients with depression, 74,160 (36.9%) had diabetes mellitus, including 57,418 (28.6%) with complications. The incidence of serious psychiatric outcomes was 3.3% in patients with depression without diabetes and 6.7% in patients with depression and diabetes mellitus. Patients with depression and diabetes mellitus complications showed higher rates of serious outcomes than that did those without diabetes mellitus complications (odds ratio, 1.19; 95% confidence interval, 1.11-1.13). Similarly, depressed patients with micro and macrovascular diabetic complications were more likely to experience serious outcomes than those without diabetes mellitus complications (odds ratio, 2.2; 95% confidence interval, 2.07-2.34). CONCLUSIONS: Our results showed that comorbid diabetes mellitus can increase the risk of serious outcomes of depression, such as suicide and hospitalization, and thus may alter the antidepressants prescription patterns and healthcare service use among patients with depressive disorders.
OBJECTIVES:Depression and diabetes are closely biologically and behaviorally intertwined. We examined the impact of comorbid diabetes mellitus on the incidence of serious psychiatric outcomes among patients with depression. METHODS: We used claims data from the Korean Health Insurance Review & Assessment Service database of patients who were diagnosed with depression within one year of an index prescription for antidepressants between January 2007 and June 2008. We investigated the association between the comorbidity of diabetes mellitus and serious psychiatric outcomes of depression, such as psychiatric hospitalization, psychiatric emergency room visits, and suicide attempts. RESULTS: Among 200,936 patients with depression, 74,160 (36.9%) had diabetes mellitus, including 57,418 (28.6%) with complications. The incidence of serious psychiatric outcomes was 3.3% in patients with depression without diabetes and 6.7% in patients with depression and diabetes mellitus. Patients with depression and diabetes mellitus complications showed higher rates of serious outcomes than that did those without diabetes mellitus complications (odds ratio, 1.19; 95% confidence interval, 1.11-1.13). Similarly, depressedpatients with micro and macrovascular diabetic complications were more likely to experience serious outcomes than those without diabetes mellitus complications (odds ratio, 2.2; 95% confidence interval, 2.07-2.34). CONCLUSIONS: Our results showed that comorbid diabetes mellitus can increase the risk of serious outcomes of depression, such as suicide and hospitalization, and thus may alter the antidepressants prescription patterns and healthcare service use among patients with depressive disorders.