Sarah Tansley1, Lucy R Wedderburn. 1. aRoyal National Hospital of Rheumatic Diseases, Bath bUniversity of Bath cInfection, Immunology, and Rheumatology Section, UCL Institute of Child Health and Arthritis Research UK Centre for Adolescent Rheumatology at UCL, UCLH and GOSH, London, UK.
Abstract
PURPOSE OF REVIEW: To explore the different characteristics of the serological phenotypes identified in juvenile and adult myositis, consider how differences between the two groups might be explained and discuss how this enhances our understanding of disease pathogenesis. RECENT FINDINGS: Current research has focussed on two main areas: first, defining the autoantibody associated disease phenotype in greater detail, particularly with regard to cutaneous disease and within specified populations such as juvenile-onset disease and different ethnic groups, and second, we have gained new insights into disease pathogenesis through studies analysing genetic associations and autoantigen expression. SUMMARY: Although there are many clinically important differences between adult and juvenile-onset myositis, recent work has highlighted many of the similarities at least within autoantibody-defined subgroups. Viewing age at disease onset as a continuum with its own influence on disease phenotype strengthens the ability of autoantibodies to define homogenous disease groups, and may be important in understanding the relationship between autoantibodies and disease pathogenesis.
PURPOSE OF REVIEW: To explore the different characteristics of the serological phenotypes identified in juvenile and adult myositis, consider how differences between the two groups might be explained and discuss how this enhances our understanding of disease pathogenesis. RECENT FINDINGS: Current research has focussed on two main areas: first, defining the autoantibody associated disease phenotype in greater detail, particularly with regard to cutaneous disease and within specified populations such as juvenile-onset disease and different ethnic groups, and second, we have gained new insights into disease pathogenesis through studies analysing genetic associations and autoantigen expression. SUMMARY: Although there are many clinically important differences between adult and juvenile-onset myositis, recent work has highlighted many of the similarities at least within autoantibody-defined subgroups. Viewing age at disease onset as a continuum with its own influence on disease phenotype strengthens the ability of autoantibodies to define homogenous disease groups, and may be important in understanding the relationship between autoantibodies and disease pathogenesis.
Authors: Rae S M Yeung; Salvatore Albani; Brian M Feldman; Elizabeth Mellins; Berent Prakken; Lucy R Wedderburn Journal: Nat Rev Rheumatol Date: 2016-09-22 Impact factor: 20.543
Authors: Sarah L Tansley; Stefania Simou; Gavin Shaddick; Zoe E Betteridge; Beverley Almeida; Harsha Gunawardena; Wendy Thomson; Michael W Beresford; Angela Midgley; Francesco Muntoni; Lucy R Wedderburn; Neil J McHugh Journal: J Autoimmun Date: 2017-06-26 Impact factor: 7.094
Authors: Alexander Oldroyd; Jamie C Sergeant; Paul New; Neil J McHugh; Zoe Betteridge; Janine A Lamb; William E Ollier; Robert G Cooper; Hector Chinoy Journal: Rheumatology (Oxford) Date: 2019-04-01 Impact factor: 7.580
Authors: Claire T Deakin; John Bowes; Lisa G Rider; Frederick W Miller; Lauren M Pachman; Helga Sanner; Kelly Rouster-Stevens; Gulnara Mamyrova; Rodolfo Curiel; Brian M Feldman; Adam M Huber; Ann M Reed; Heinrike Schmeling; Charlotte G Cook; Lucy R Marshall; Meredyth G Ll Wilkinson; Stephen Eyre; Soumya Raychaudhuri; Lucy R Wedderburn Journal: Hum Mol Genet Date: 2022-07-21 Impact factor: 5.121
Authors: S Soponkanaporn; C T Deakin; P W Schutz; L R Marshall; S A Yasin; C M Johnson; E Sag; S L Tansley; N J McHugh; L R Wedderburn; T S Jacques Journal: Neuropathol Appl Neurobiol Date: 2018-06-04 Impact factor: 8.090