Literature DB >> 26352161

The Thrombospondin1-TGF-β Pathway and Glaucoma.

Joanne E Murphy-Ullrich1,2,3, J Crawford Downs3,4.   

Abstract

Glaucoma is characterized by abnormal remodeling of the extracellular matrix (ECM) in the trabecular meshwork and in the connective tissue beams of the lamina cribrosa (LC) at the optic nerve head (ONH), which is associated with axonal damage. Mechanical strain can stimulate ECM remodeling and increased expression of matricellular proteins. Thrombospondins 1 and 2 are induced by cyclic mechanical strain in the eye in both the trabecular meshwork and in the LC region of the ONH. TGF-betas 1 and 2 are increased in glaucoma and play a role in the pathologic remodeling of the ECM in the eye in glaucoma. In this study, we address the role of thrombospondin1 as a regulator of latent TGF-beta activation and discuss the potential therapeutic use of antagonists of the thrombospondin1-TGF-beta pathway for treatment of glaucoma.

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Year:  2015        PMID： 26352161      PMCID： PMC7366264          DOI： 10.1089/jop.2015.0016

Source DB:  PubMed          Journal:  J Ocul Pharmacol Ther        ISSN： 1080-7683            Impact factor:   2.671


  86 in total

1.  Changes in gene expression by trabecular meshwork cells in response to mechanical stretching.

Authors:  Vasavi Vittal; Anastasia Rose; Kate E Gregory; Mary J Kelley; Ted S Acott
Journal:  Invest Ophthalmol Vis Sci       Date:  2005-08       Impact factor: 4.799

2.  Changes in the extracellular matrix of the human optic nerve head in primary open-angle glaucoma.

Authors:  M R Hernandez; W M Andrzejewska; A H Neufeld
Journal:  Am J Ophthalmol       Date:  1990-02-15       Impact factor: 5.258

3.  Distribution and expression of transforming growth factor-beta and platelet-derived growth factor in the normal and glaucomatous monkey optic nerve heads.

Authors:  T Fukuchi; J Ueda; T Hanyu; H Abe; S Sawaguchi
Journal:  Jpn J Ophthalmol       Date:  2001 Nov-Dec       Impact factor: 2.447

Review 4.  Making sense of latent TGFbeta activation.

Authors:  Justin P Annes; John S Munger; Daniel B Rifkin
Journal:  J Cell Sci       Date:  2003-01-15       Impact factor: 5.285

5.  Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species.

Authors:  Michael F Jobling; Joni D Mott; Monica T Finnegan; Vladimir Jurukovski; Anna C Erickson; Peter J Walian; Scott E Taylor; Steven Ledbetter; Catherine M Lawrence; Daniel B Rifkin; Mary Helen Barcellos-Hoff
Journal:  Radiat Res       Date:  2006-12       Impact factor: 2.841

6.  Morphologic changes in the lamina cribrosa correlated with neural loss in open-angle glaucoma.

Authors:  H A Quigley; R M Hohman; E M Addicks; R W Massof; W R Green
Journal:  Am J Ophthalmol       Date:  1983-05       Impact factor: 5.258

7.  Thrombospondin-1 (TSP1)-null and TSP2-null mice exhibit lower intraocular pressures.

Authors:  Ramez I Haddadin; Dong-Jin Oh; Min Hyung Kang; Guadalupe Villarreal; Ja-Heon Kang; Rui Jin; Haiyan Gong; Douglas J Rhee
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-09-28       Impact factor: 4.799

Review 8.  The thrombospondins.

Authors:  Josephine C Adams; Jack Lawler
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-10-01       Impact factor: 10.005

9.  Enhanced tenascin expression associated with reactive astrocytes in human optic nerve heads with primary open angle glaucoma.

Authors:  J D Pena; H J Varela; C S Ricard; M R Hernandez
Journal:  Exp Eye Res       Date:  1999-01       Impact factor: 3.467

10.  Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1.

Authors:  P Bornstein
Journal:  J Cell Biol       Date:  1995-08       Impact factor: 10.539
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  8 in total

Review 1.  Lamina cribrosa in glaucoma.

Authors:  J Crawford Downs; Christopher A Girkin
Journal:  Curr Opin Ophthalmol       Date:  2017-03       Impact factor: 3.761

Review 2.  Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease.

Authors:  Joanne E Murphy-Ullrich; Mark J Suto
Journal:  Matrix Biol       Date:  2017-12-27       Impact factor: 11.583

Review 3.  Thrombospondin-1 Signaling Through the Calreticulin/LDL Receptor Related Protein 1 Axis: Functions and Possible Roles in Glaucoma.

Authors:  Joanne E Murphy-Ullrich
Journal:  Front Cell Dev Biol       Date:  2022-05-27

Review 4.  Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork-A review.

Authors:  Kate E Keller; Donna M Peters
Journal:  Clin Exp Ophthalmol       Date:  2022-01-17       Impact factor: 4.383

Review 5.  Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma.

Authors:  Ryan G Strickland; Mary Anne Garner; Alecia K Gross; Christopher A Girkin
Journal:  Int J Mol Sci       Date:  2022-07-22       Impact factor: 6.208

6.  Glucocorticoid-induced cell-derived matrix modulates transforming growth factor β2 signaling in human trabecular meshwork cells.

Authors:  Felix Yemanyi; Janice Vranka; Vijay Krishna Raghunathan
Journal:  Sci Rep       Date:  2020-09-24       Impact factor: 4.379

Review 7.  Cell-Matrix Interactions in the Eye: From Cornea to Choroid.

Authors:  Andrew E Pouw; Mark A Greiner; Razek G Coussa; Chunhua Jiao; Ian C Han; Jessica M Skeie; John H Fingert; Robert F Mullins; Elliott H Sohn
Journal:  Cells       Date:  2021-03-20       Impact factor: 7.666

Review 8.  Replacement of the Trabecular Meshwork Cells-A Way Ahead in IOP Control?

Authors:  Xiaochen Fan; Emine K Bilir; Olivia A Kingston; Rachel A Oldershaw; Victoria R Kearns; Colin E Willoughby; Carl M Sheridan
Journal:  Biomolecules       Date:  2021-09-16
  8 in total

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