| Literature DB >> 26351088 |
Nicola Veronese1, Anna Zurlo2, Marco Solmi3, Claudio Luchini4, Caterina Trevisan2, Giulia Bano2, Enzo Manzato5, Giuseppe Sergi2, Ragnar Rylander6.
Abstract
The interest in poor magnesium (Mg) status as risk factor for Alzheimer's disease (AD) is increasing due to its antioxidant and neuroprotective properties. A systematic PubMed literature search of studies investigating Mg status was undertaken comparing AD to healthy controls (HCs) or patients with medical illness (medical controls [MCs]). Standardized mean differences (SMDs) ± 95% confidence intervals (CIs) were calculated for all outcomes. Of 192 potentially eligible studies, 13 were included (559 patients with AD, 381 HCs, and 126 MCs). Compared to HCs, patients with AD had significantly lower Mg in cerebrospinal fluid (2 studies; SMD = -0.35;P= .02) and in hair (2 studies; SMD = -0.75;P= .0001). No differences between AD and controls were evident for serum Mg. In conclusion, AD seems to be associated with a lower Mg status when compared to HCs, while the scarcity of studies limited the findings about MCs.Entities:
Keywords: Alzheimer’s disease; aging; dementia; healthy controls; magnesium
Mesh：
Substances：
Year: 2015 PMID： 26351088 DOI： 10.1177/1533317515602674
Source DB: PubMed Journal: Am J Alzheimers Dis Other Demen ISSN： 1533-3175 Impact factor: 2.035