Susanna Conti1, Giada Minelli1, Valeria Ascoli2, Alessandro Marinaccio3, Michela Bonafede3, Valerio Manno1, Roberta Crialesi4, Kurt Straif5. 1. Unit of Statistics, National Institute of Public Health (Istituto Superiore di Sanità), Rome, Italy. 2. Department of Radiological, Oncological and Pathological Sciences, Sapienza University, Rome, Italy. 3. Occupational Medicine Department, Italian Workers Compensation Authority (INAIL) research area, Italian National Mesothelioma Register (ReNaM), Rome, Italy. 4. National Institute of Statistics (ISTAT), Rome, Italy. 5. International Agency for Research on Cancer (IARC), Lyon, France.
Abstract
INTRODUCTION: Peritoneal mesothelioma, a very rare and lethal malignancy, has not been investigated as extensively as pleural mesothelioma, although the role of asbestos exposure in its occurrence is well-known. Data from Italy are relevant, as it was the largest European asbestos producer, and asbestos was widely used in many economic activities. METHODS: A population-based mortality and incidence analysis was performed in Italy. Data sources were the National Multiple-causes-of-death Database (1995-2010) and the Italian Mesothelioma Register (1993-2008). RESULTS: We found an increasing trend of age standardized mortality rates in men, but no clear trend in women; moreover, we showed significant risks of death in several northern regions, formerly heavy asbestos users; finally, mortality/incidence ratios similar for both genders (about 0.8) were estimated. CONCLUSIONS: The study, based on national data, showed a higher risk of mortality from and incidence of peritoneal mesothelioma in areas with formerly heavy exposure to asbestos.
INTRODUCTION:Peritoneal mesothelioma, a very rare and lethal malignancy, has not been investigated as extensively as pleural mesothelioma, although the role of asbestos exposure in its occurrence is well-known. Data from Italy are relevant, as it was the largest European asbestos producer, and asbestos was widely used in many economic activities. METHODS: A population-based mortality and incidence analysis was performed in Italy. Data sources were the National Multiple-causes-of-death Database (1995-2010) and the Italian Mesothelioma Register (1993-2008). RESULTS: We found an increasing trend of age standardized mortality rates in men, but no clear trend in women; moreover, we showed significant risks of death in several northern regions, formerly heavy asbestos users; finally, mortality/incidence ratios similar for both genders (about 0.8) were estimated. CONCLUSIONS: The study, based on national data, showed a higher risk of mortality from and incidence of peritoneal mesothelioma in areas with formerly heavy exposure to asbestos.
Authors: Dario Consonni; Cristina Calvi; Sara De Matteis; Dario Mirabelli; Maria Teresa Landi; Neil E Caporaso; Susan Peters; Roel Vermeulen; Hans Kromhout; Barbara Dallari; Angela Cecilia Pesatori; Luciano Riboldi; Carolina Mensi Journal: Occup Environ Med Date: 2019-07-08 Impact factor: 4.402