| Literature DB >> 26350451 |
Haiying Chen1, Lihong Huang1, Hui Li1, Xianfeng Zhou1, Huanan Li1, Na Sun1, Wenbao Qi1, Chencheng Xiao1, Xiansheng Ni1, Mingbin Liu1, Ming Liao2.
Abstract
Three human cases of H10N8 virus infections were initially reported in China in late 2013 and early 2014, two of which were fatal. This was the first time the H10N8 subtype has been detected in humans, and the pathogenicity of this virus remains under characterized. We first assessed its pathogenicity by infecting BALB/c mice with two H10N8 isolates, A/Jiangxi-Donghu/346-1/2013 and A/Chicken/Jiangxi/102/2013. The human isolate (H346-1) demonstrated stronger capability of replication and induced higher cytokine response in vivo than the chicken isolate (C102). In addition, H346-1 was fatal to mice, while all mice (N = 14) in C102-infected group survived during the infection course without weight loss. We hypothesized that the 627K mutation in the PB2 gene (PB2-K627) in H346-1 was associated with high pathogenicity in mice. Taken together, this study based on mouse model provides some insight into understanding the pathogenicity of the emerging viruses in mammals. © The American Society of Tropical Medicine and Hygiene.Entities:
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Year: 2015 PMID： 26350451 PMCID： PMC4674259 DOI： 10.4269/ajtmh.15-0064
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 2.345