| Literature DB >> 26350221 |
V Floré1,2, P Claus3, M A Vos4, B Vandenberk5, S Van Soest5, K R Sipido5, T Adriaenssens6, J Bogaert7, W Desmet6, R Willems5,6.
Abstract
The purpose of this study is to investigate the relationship between T-wave alternans (TWA), infarct size and microvascular obstruction (MVO) and recurrent cardiac morbidity after ST elevation myocardial infarction (STEMI). One hundred six patients underwent TWA testing 1-12 months and 57 patients underwent cardiac magnetic resonance imaging (MRI) in the first 2-4 days after STEMI. During follow-up (3.5 ± 0.5 years), death (n = 2), ventricular tachycardia (n = 3), supraventricular tachycardia (n = 4), heart failure (n = 3) and recurrent coronary ischemia (n = 25) were observed. After multivariate analysis, positive TWA (HR2.59, CI1.10-6.11, p0.024) and larger MVO (HR1.08, CI1.01-1.16, p0.034) were associated with recurrent angina or ACS. Presence of MVO was correlated with TWA (Spearman rho 0.404, p0.002) and the impairment of LVEF (-0.524, p < 0.001). Patients after STEMI remain at a high risk of symptoms of coronary ischemia. The presence of MVO and TWA 1-12 months after STEMI is related to each other and to recurrent angina or ACS.Entities:
Keywords: Cardiac magnetic resonance imaging; Microvascular obstruction; Non-invasive risk stratification; ST segment elevation myocardial infarction; t-wave alternans
Mesh：
Year: 2015 PMID： 26350221 DOI： 10.1007/s12265-015-9649-x
Source DB: PubMed Journal: J Cardiovasc Transl Res ISSN： 1937-5387 Impact factor: 4.132