Valentina Rosato1, Cristina Bosetti1, Luigino Dal Maso2, Maurizio Montella3, Diego Serraino2, Eva Negri1, Carlo La Vecchia4. 1. Department of Epidemiology, Mario Negri Institute for Pharmacological Research, IRCCS, Milan - Italy. 2. Unit of Epidemiology and Biostatistics, CRO Aviano National Cancer Institute IRCCS, Aviano (Pordenone) - Italy. 3. Unit of Epidemiology, National Cancer Institute "G. Pascale Foundation", Naples - Italy. 4. Department of Clinical Sciences and Community Health, University of Milan, Milan - Italy.
Abstract
BACKGROUND: Scanty data exist on the role of personal medical conditions, except for gallstones, and family history of cancer on the risk of biliary tract cancers (BTC). METHODS: We analyzed this issue using data from two Italian case-control studies, including 159 cases of BTC and 795 matched hospital controls. Odds ratios (ORs) of BTC and corresponding 95% confidence intervals (CIs) were estimated using multiple logistic regression models. RESULTS: Gallstones were associated with a 2-fold excess risk of BTC (95% CI 1.24-3.45). No significant associations were observed with other conditions investigated, including diabetes (OR 1.15, 95% CI 0.63-2.11), hypertension (OR 0.65, 95% CI 0.39-1.11), hyperlipidemia (OR 0.61, 95% CI 0.31-1.21), allergy (OR 0.64, 95% CI 0.29-1.40), gastroduodenal ulcer (OR 0.52, 95% CI 0.24-1.12), hepatitis (OR 2.02, 95% CI 0.35-11.67), benign thyroid diseases (OR 1.16, 95% CI 0.56-2.40), hysterectomy (OR 1.19, 95% CI 0.53-2.68), unilateral oophorectomy (OR 1.75, 95% CI 0.44-6.93), and bilateral oophorectomy (OR 2.48, 95% CI 0.79-7.82). We found an excess risk of BTC in relation to family history of any cancer (OR 1.52, 95% CI 1.03-2.24) and family history of gallbladder cancer (OR 3.83, 95% CI 0.59-24.75). CONCLUSIONS: The present study confirms a strong association between BTC and history of gallstones, and provides further evidence of a positive association with family history of cancer.
BACKGROUND: Scanty data exist on the role of personal medical conditions, except for gallstones, and family history of cancer on the risk of biliary tract cancers (BTC). METHODS: We analyzed this issue using data from two Italian case-control studies, including 159 cases of BTC and 795 matched hospital controls. Odds ratios (ORs) of BTC and corresponding 95% confidence intervals (CIs) were estimated using multiple logistic regression models. RESULTS:Gallstones were associated with a 2-fold excess risk of BTC (95% CI 1.24-3.45). No significant associations were observed with other conditions investigated, including diabetes (OR 1.15, 95% CI 0.63-2.11), hypertension (OR 0.65, 95% CI 0.39-1.11), hyperlipidemia (OR 0.61, 95% CI 0.31-1.21), allergy (OR 0.64, 95% CI 0.29-1.40), gastroduodenal ulcer (OR 0.52, 95% CI 0.24-1.12), hepatitis (OR 2.02, 95% CI 0.35-11.67), benign thyroid diseases (OR 1.16, 95% CI 0.56-2.40), hysterectomy (OR 1.19, 95% CI 0.53-2.68), unilateral oophorectomy (OR 1.75, 95% CI 0.44-6.93), and bilateral oophorectomy (OR 2.48, 95% CI 0.79-7.82). We found an excess risk of BTC in relation to family history of any cancer (OR 1.52, 95% CI 1.03-2.24) and family history of gallbladder cancer (OR 3.83, 95% CI 0.59-24.75). CONCLUSIONS: The present study confirms a strong association between BTC and history of gallstones, and provides further evidence of a positive association with family history of cancer.
Authors: Alison L Van Dyke; Margaret S Langhamer; Bin Zhu; Ruth M Pfeiffer; Demetrius Albanes; Gabriella Andreotti; Laura E Beane Freeman; Andrew T Chan; Neal D Freedman; Susan M Gapstur; Graham G Giles; Francine Grodstein; Linda M Liao; Juhua Luo; Roger L Milne; Kristine R Monroe; Marian L Neuhouser; Jenny N Poynter; Mark P Purdue; Kim Robien; Catherine Schairer; Rashmi Sinha; Stephanie Weinstein; Xuehong Zhang; Jessica L Petrick; Katherine A McGlynn; Peter T Campbell; Jill Koshiol Journal: Cancer Epidemiol Biomarkers Prev Date: 2018-01-16 Impact factor: 4.254
Authors: Kwondo Kim; DongAhn Yoo; Hee Seung Lee; Kyong Joo Lee; Soo Been Park; Chanyang Kim; Jung Hyun Jo; Dawoon E Jung; Si Young Song Journal: BMC Med Genomics Date: 2019-05-16 Impact factor: 3.063