Literature DB >> 26349990

New insights of medicinal plant therapeutic activity-The miRNA transfer.

Maria Sala-Cirtog1, Catalin Marian1, Andrei Anghel2.   

Abstract

MicroRNA (miRNA) has become the spotlight of the biomedical research around the world and is considered to be a major post-transcriptional gene regulator. This small, endogenous RNA (21-25 nucleotides long) plays an important role by targeting specific mRNAs in plants, animals and humans. Herbal medicine has been used for thousands of years, however little is known about its molecular mechanism of action. Since the discovery of plant miRNA in human tissue and sera after ingestion, the connection between the two kingdoms is presented under a new perspective. Forward pharmacology, such as miRNA therapeutics could be the next best step toward identifying novel therapeutic options involving medicinal plants. Besides reporting the latest findings regarding the cross-kingdom transfer of miRNA and its therapeutic application, this review can inform further investigations that could lead to a modern definition of herbal medicine.
Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Cross-kingdom transfer; Exosomes; Phytotherapy; microRNA

Mesh：

Substances：

Year:  2015        PMID： 26349990     DOI： 10.1016/j.biopha.2015.08.016

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN： 0753-3322            Impact factor:   6.529


  7 in total

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2.  Small RNA profiling for identification of miRNAs involved in regulation of saponins biosynthesis in Chlorophytum borivilianum.

Authors:  Monika Kajal; Kashmir Singh
Journal:  BMC Plant Biol       Date:  2017-12-28       Impact factor: 4.215

3.  Olea europaea small RNA with functional homology to human miR34a in cross-kingdom interaction of anti-tumoral response.

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Journal:  Sci Rep       Date:  2018-08-17       Impact factor: 4.379

4.  MepmiRDB: a medicinal plant microRNA database.

Authors:  Dongliang Yu; Jiangjie Lu; Weishan Shao; Xiaoxia Ma; Tian Xie; Hidetaka Ito; Tingzhang Wang; Min Xu; Huizhong Wang; Yijun Meng
Journal:  Database (Oxford)       Date:  2019-01-01       Impact factor: 3.451

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6.  Garmultin-A Incites Apoptosis in CB3 Cells Through miR-17-5p by Attenuating Poly (ADP-Ribose) Polymerase-1.

Authors:  Jianfei Qiu; Li Chen; Jue Yang; Krishnapriya M Varier; Babu Gajendran; Yao Yao; Wuling Liu; Jingrui Song; Qing Rao; Qun Long; Chunmao Yuan; Xiaojiang Hao; Yanmei Li
Journal:  Dose Response       Date:  2022-10-11       Impact factor: 2.623

7.  Ginger-derived nanoparticles protect against alcohol-induced liver damage.

Authors:  Xiaoying Zhuang; Zhong-Bin Deng; Jingyao Mu; Lifeng Zhang; Jun Yan; Donald Miller; Wenke Feng; Craig J McClain; Huang-Ge Zhang
Journal:  J Extracell Vesicles       Date:  2015-11-25
  7 in total

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