| Literature DB >> 26348786 |
Pawan Kumar Maurya1, Cristiano Noto2, Lucas B Rizzo3, Adiel C Rios2, Sandra O V Nunes4, Décio Sabbatini Barbosa4, Sumit Sethi2, Maiara Zeni2, Rodrigo B Mansur5, Michael Maes6, Elisa Brietzke7.
Abstract
Major depressive disorder (MDD) affects millions of individuals and is highly comorbid with many age associated diseases such as diabetes mellitus, immune-inflammatory dysregulation and cardiovascular diseases. Oxidative/nitrosative stress plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative/neuropsychiatric disorders including MDD. In this review, we critically review the evidence for an involvement of oxidative/nitrosative stress in acceleration of aging process in MDD. There are evidence of the association between MDD and changes in molecular mechanisms involved in aging. There is a significant association between telomere length, enzymatic antioxidant activities (SOD, CAT, GPx), glutathione (GSH), lipid peroxidation (MDA), nuclear factor κB, inflammatory cytokines with MDD. Major depression also is characterized by significantly lower concentration of antioxidants (zinc, coenzyme Q10, PON1). Since, aging and MDD share a common biological base in their pathophysiology, the potential therapeutic use of antioxidants and anti-aging molecules in MDD could be promising.Entities:
Keywords: Accelerated aging; Clinical implications; Major depressive disorder; Oxidative stress
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Year: 2015 PMID： 26348786 DOI： 10.1016/j.pnpbp.2015.08.016
Source DB: PubMed Journal: Prog Neuropsychopharmacol Biol Psychiatry ISSN： 0278-5846 Impact factor: 5.067