Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization.

Literature DB >> 26348484

Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization.

Sung Jae Yang¹, Hyoung Jo², Kyung-A Kim^2,3, Hong Ryul Ahn², Suk Woo Kang², Sang Hoon Jung^2,3.

Abstract

The purpose of this study was to evaluate the effect of ethanol extract of Diospyros kaki (EEDK) leaves on corneal neovascularization (CoNV) in rats. One week after the alkali burns in the corneas, the CoNV area coverage in the CoNV-positive control group, 100 mg/kg EEDK group, and 200 mg/kg EEDK group was 43.3% ± 5.5%, 337.7% ± 2.5%, and 27.2% ± 4.3%, respectively. The areas of CoNV in the EEDK-treated groups were significantly different from those of the CoNV group. EEDK significantly attenuated the upregulation of vascular endothelial growth factor, fibroblast growth factor, interleukin-6, and matrix metalloproteinase-2 (MMP-2) protein levels. Orally administrated D. kaki inhibited CoNV development in rats.

Entities: Chemical Disease Species

Keywords: Diospyros kaki; alkali burn; angiogenic factors; corneal neovascularization; eye diseases

Mesh：

Substances：

Year: 2015 PMID： 26348484 PMCID： PMC4717495 DOI： 10.1089/jmf.2014.3404

Source DB: PubMed Journal: J Med Food ISSN： 1096-620X Impact factor: 2.786

14 in total

1. Comparative contents of dietary fiber, total phenolics, and minerals in persimmons and apples.

Authors: S Gorinstein; Z Zachwieja; M Folta; H Barton; J Piotrowicz; M Zemser; M Weisz; S Trakhtenberg; O Màrtín-Belloso
Journal: J Agric Food Chem Date: 2001-02 Impact factor: 5.279

Review 2. Corneal neovascularization.

Authors: J H Chang; E E Gabison; T Kato; D T Azar
Journal: Curr Opin Ophthalmol Date: 2001-08 Impact factor: 3.761

Review 3. CXC chemokines in angiogenesis.

Authors: Robert M Strieter; Marie D Burdick; Brigitte N Gomperts; John A Belperio; Michael P Keane
Journal: Cytokine Growth Factor Rev Date: 2005-07-19 Impact factor: 7.638

4. Absence of histologic retinal toxicity of intravitreal bevacizumab in a rabbit model.

Authors: Sophie J Bakri; J Douglas Cameron; Colin A McCannel; Jose S Pulido; Ronald J Marler
Journal: Am J Ophthalmol Date: 2006-07 Impact factor: 5.258

5. Cytokine expression in the alkali-burned cornea.

Authors: C Sotozono; J He; Y Matsumoto; M Kita; J Imanishi; S Kinoshita
Journal: Curr Eye Res Date: 1997-07 Impact factor: 2.424

6. Expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in inflammation-induced corneal neovascularization.

Authors: D H Ma; J K Chen; W S Kim; Y X Hao; H C Wu; R J Tsai; D G Hwang; F Zhang
Journal: Ophthalmic Res Date: 2001 Nov-Dec Impact factor: 2.892

7. Neuroprotective effects of a standardized flavonoid extract from Diospyros kaki leaves.

Authors: Weijian Bei; Linquan Zang; Jiao Guo; Wenlie Peng; Anlong Xu; David A Good; Yinming Hu; Wei Wu; Dehui Hu; Xinghong Zhu; Ming Wei; Chuyuan Li
Journal: J Ethnopharmacol Date: 2009-08-07 Impact factor: 4.360

8. Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali.

Authors: Shizuya Saika; Kazuo Ikeda; Osamu Yamanaka; Takeshi Miyamoto; Yoshitaka Ohnishi; Misako Sato; Yasuteru Muragaki; Akira Ooshima; Yuji Nakajima; Winston W-Y Kao; Kathleen C Flanders; Anita B Roberts
Journal: Am J Pathol Date: 2005-05 Impact factor: 4.307

9. Expression of matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) in inflammation-associated corneal neovascularization.

Authors: A Kvanta; S Sarman; P Fagerholm; S Seregard; B Steen
Journal: Exp Eye Res Date: 2000-04 Impact factor: 3.467

Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization.

1. Comparative contents of dietary fiber, total phenolics, and minerals in persimmons and apples.

Review 2. Corneal neovascularization.

Review 3. CXC chemokines in angiogenesis.

4. Absence of histologic retinal toxicity of intravitreal bevacizumab in a rabbit model.

5. Cytokine expression in the alkali-burned cornea.

6. Expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in inflammation-induced corneal neovascularization.

7. Neuroprotective effects of a standardized flavonoid extract from Diospyros kaki leaves.

8. Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali.

9. Expression of matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) in inflammation-associated corneal neovascularization.

10. Preparing a carotenoid polyphenol-enriched extract from the peel of persimmon, Diospyros kaki L.f.

Review 1. Current and emerging therapies for corneal neovascularization.

Review 2. The molecular mechanisms of action of PPAR-γ agonists in the treatment of corneal alkali burns (Review).

3. Effect of Collagen Cross-Linking on Alkali Burn-Induced Corneal Neovascularization in Rabbits.

4. The leaves of Diospyros kaki exert beneficial effects on a benzalkonium chloride-induced murine dry eye model.

5. Protective Effect of Diospyros kaki against Glucose-Oxygen-Serum Deprivation-Induced PC12 Cells Injury.