Vittorio Capuano1, Eric H Souied2, Alexandra Miere1, Camille Jung3, Eliana Costanzo1, Giuseppe Querques2. 1. Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France. 2. Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France Groupe de Recherche Clinique Macula, Universite Paris Est, Creteil, France. 3. Groupe de Recherche Clinique Macula, Universite Paris Est, Creteil, France Centre de Ressources Biologiques et Centre de Recherche Clinique du Centre Hopitalier Intercommunal de Créteil, Creteil, France.
Abstract
PURPOSE: To compare choroidal thickness maps (CMs) in patients with non-exudative age-related macular degeneration (AMD) and control subjects using swept source optical coherence tomography (Swept-OCT). METHODS: CMs were automatically measured in the different Early Treatment of Diabetic Retinopathy Study (ETDRS) sectors in eyes with early non-exudative AMD (early AMD) (large soft drusen: group 1; reticular pseudodrusen: group 2 and variable combination of large soft drusen and reticular pseudodrusen: group 3), late non-exudative AMD/geographic atrophy (GA) (late AMD) (group 4) and control subjects (group 5). Fundus autofluorescence (FAF) images were overlaid to sectorial CMs in late-AMD group (group 4). RESULTS: A total of 90 eyes (90 patients, 79.7±8.34 years old) were included. CMs were significantly reduced in early-AMD group 2 and 3 and late-AMD group 4 compared with control subjects in group 5 and early-AMD group 1 (large soft drusen alone) for each ETDRS sectors (p<0.05). No difference in CMs was found by comparing group 2 with 3 and group 2 and 3 with group 4. No statistical differences in CMs were found among ETDRS sectors with >50% absence of FAF ('Hypo FAF' sectors) resulting from retinal atrophy versus ≤50% absence of FAF ('hyper/iso FAF' sectors owing to >50% preserved retina) in late-AMD group (group 4) (p=0.328). CONCLUSIONS: CMs appeared thinner in early non-exudative AMD with intermediate distribution of reticular pseudodrusen versus control subjects and early non-exudative AMD with drusen alone. Same results were found in the group with variable combination of large soft drusen and reticular pseudodrusen. In GA eyes, a choroidal thinning could be detected independently of the retinal pigmented epithelium status. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
PURPOSE: To compare choroidal thickness maps (CMs) in patients with non-exudative age-related macular degeneration (AMD) and control subjects using swept source optical coherence tomography (Swept-OCT). METHODS: CMs were automatically measured in the different Early Treatment of Diabetic Retinopathy Study (ETDRS) sectors in eyes with early non-exudative AMD (early AMD) (large soft drusen: group 1; reticular pseudodrusen: group 2 and variable combination of large soft drusen and reticular pseudodrusen: group 3), late non-exudative AMD/geographic atrophy (GA) (late AMD) (group 4) and control subjects (group 5). Fundus autofluorescence (FAF) images were overlaid to sectorial CMs in late-AMD group (group 4). RESULTS: A total of 90 eyes (90 patients, 79.7±8.34 years old) were included. CMs were significantly reduced in early-AMD group 2 and 3 and late-AMD group 4 compared with control subjects in group 5 and early-AMD group 1 (large soft drusen alone) for each ETDRS sectors (p<0.05). No difference in CMs was found by comparing group 2 with 3 and group 2 and 3 with group 4. No statistical differences in CMs were found among ETDRS sectors with >50% absence of FAF ('Hypo FAF' sectors) resulting from retinal atrophy versus ≤50% absence of FAF ('hyper/iso FAF' sectors owing to >50% preserved retina) in late-AMD group (group 4) (p=0.328). CONCLUSIONS: CMs appeared thinner in early non-exudative AMD with intermediate distribution of reticular pseudodrusen versus control subjects and early non-exudative AMD with drusen alone. Same results were found in the group with variable combination of large soft drusen and reticular pseudodrusen. In GA eyes, a choroidal thinning could be detected independently of the retinal pigmented epithelium status. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
Authors: Rebecca J Sardell; Muneeswar G Nittala; Larry D Adams; Reneé A Laux; Jessica N Cooke Bailey; Denise Fuzzell; Sarada Fuzzell; Lori Reinhart-Mercer; Laura J Caywood; Violet Horst; Tine Mackay; Debbie Dana; SriniVas R Sadda; William K Scott; Dwight Stambolian; Jonathan L Haines; Margaret A Pericak-Vance Journal: Ophthalmology Date: 2016-10-19 Impact factor: 12.079
Authors: Alessandro Rabiolo; Riccardo Sacconi; Maria Vittoria Cicinelli; Lea Querques; Francesco Bandello; Giuseppe Querques Journal: Clin Ophthalmol Date: 2017-09-20