Ana Batalla1, Eliecer Coto2, Leire González-Lara1, Daniel González-Fernández1, Juan Gómez3, Tamara F Aranguren3, Rubén Queiro4, Jorge Santos-Juanes1, Carlos López-Larrea5, Pablo Coto-Segura6. 1. Department of Dermatology II, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain. 2. Department of Molecular Genetics, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain; Department of Medicine, Universidad de Oviedo, Calle San Francisco, 1, 33003 Oviedo, Spain. 3. Department of Molecular Genetics, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain. 4. Department of Rheumatology, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain. 5. Department of Immunology, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain. 6. Department of Dermatology II, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain; Department of Medicine, Universidad de Oviedo, Calle San Francisco, 1, 33003 Oviedo, Spain. Electronic address: cotopablo@uniovi.es.
Abstract
BACKGROUND: The IL17 pathway plays an important role in the pathogenesis of psoriasis (PsO). OBJECTIVES: To determine whether the variation at the IL17 pathway genes was linked to the risk for PsO or had an effect on disease severity and the risk for Psoriatic arthritis (PsA). METHODS: Cross-sectional observational study of 580 psoriasis patients and 567 healthy controls who were genotyped for six single nucleotide polymorphisms (SNPs) in the IL17RA (rs4819554, rs879577), IL17A (rs7747909), IL17F (rs763780, rs2397084), and IL17E (rs79877597) genes. RESULTS: We found significant higher frequencies of IL17RA rs4819554 G carriers among the patients (OR=1.33, 95%CI=1.05-1.69; p=0.017). The IL17RA rs4819554 G allele and IL17F rs2397084 TT genotype were significantly more frequent among Cw6 positive patients (p=0.037 and p=0.010, respectively). The IL17E rs79877597C allele was significantly more common among patients with severe forms of PsO (p=0.010; OR=2.42, 95%CI=1.23-4.76), and the CC genotype with the presence of arthritis (p=0.032; OR=1.50, 95%CI=1.04-2.18). CONCLUSIONS: We identified the IL17RA rs4819554 SNP as a risk factor for PsO. The IL17E rs79877597 SNP was a modifier of the risk for PsO disease severity and PsA.
BACKGROUND: The IL17 pathway plays an important role in the pathogenesis of psoriasis (PsO). OBJECTIVES: To determine whether the variation at the IL17 pathway genes was linked to the risk for PsO or had an effect on disease severity and the risk for Psoriatic arthritis (PsA). METHODS: Cross-sectional observational study of 580 psoriasispatients and 567 healthy controls who were genotyped for six single nucleotide polymorphisms (SNPs) in the IL17RA (rs4819554, rs879577), IL17A (rs7747909), IL17F (rs763780, rs2397084), and IL17E (rs79877597) genes. RESULTS: We found significant higher frequencies of IL17RArs4819554 G carriers among the patients (OR=1.33, 95%CI=1.05-1.69; p=0.017). The IL17RArs4819554 G allele and IL17Frs2397084 TT genotype were significantly more frequent among Cw6 positive patients (p=0.037 and p=0.010, respectively). The IL17E rs79877597C allele was significantly more common among patients with severe forms of PsO (p=0.010; OR=2.42, 95%CI=1.23-4.76), and the CC genotype with the presence of arthritis (p=0.032; OR=1.50, 95%CI=1.04-2.18). CONCLUSIONS: We identified the IL17RArs4819554 SNP as a risk factor for PsO. The IL17Ers79877597 SNP was a modifier of the risk for PsO disease severity and PsA.
Authors: A Batalla; E Coto; J Gómez; N Eirís; D González-Fernández; C Gómez-De Castro; E Daudén; M Llamas-Velasco; R Prieto-Perez; F Abad-Santos; G Carretero; F S García; Y B Godoy; L F Cardo; B Alonso; S Iglesias; P Coto-Segura Journal: Pharmacogenomics J Date: 2016-09-27 Impact factor: 3.550
Authors: Jose Ramón Vidal-Castiñeira; Antonio López-Vázquez; Roberto Diaz-Peña; Paula Diaz-Bulnes; Pablo Martinez-Camblor; Eliecer Coto; Pablo Coto-Segura; Jacome Bruges-Armas; Jose Antonio Pinto; Francisco Jose Blanco; Alejandra Sánchez; Juan Mulero; Ruben Queiro; Carlos Lopez-Larrea Journal: PLoS One Date: 2016-07-14 Impact factor: 3.240
Authors: Michelle L M Mulder; Tamara W van Hal; Mark H Wenink; Hans J P M Koenen; Frank H J van den Hoogen; Elke M G J de Jong; Juul M P A van den Reek; Johanna E Vriezekolk Journal: Arthritis Res Ther Date: 2021-06-14 Impact factor: 5.156